Relationship of cumulative exposure to the triglyceride-glucose index with ischemic stroke: a 9-year prospective study in the Kailuan cohort

Wang, Xianxuan; Feng, Baoyu; Huang, Zegui; Cai, Zefeng; Yu, Xinran; Chen, Zekai; Cai, Zhiwei; Chen, Guanzhi; Wu, Shouling; Chen, Youren

doi:10.1186/s12933-022-01510-y

Cardiovascular Diabetology

Table 1 Baseline characteristics of participants by cumulative TyG index quartiles

From: Relationship of cumulative exposure to the triglyceride-glucose index with ischemic stroke: a 9-year prospective study in the Kailuan cohort

	Total	Q1	Q2	Q3	Q4	P
Participants	54,098	13,524	13,525	13,525	13,524
Age (years)	49.03 ± 11.84	44.88 ± 10.57	46.99 ± 11.50^a	50.71 ± 11.89^ab	53.54 ± 11.42^abc	< 0.01
Male, N (%)	41,157 (76.08)	9561 (70.70)	10,782 (79.72)	10,506 (77.68)	10,308 (76.22)	< 0.01
BMI (kg/m²)	25.01 ± 3.16	24.03 ± 3.04	24.84 ± 3.14^a	25.29 ± 3.10^ab	25.87 ± 3.07^abc	< 0.01
SBP (mmHg)	129.44 ± 16.88	123.71 ± 15.66	128.33 ± 15.64^a	131.63 ± 16.93^ab	134.07 ± 17.41^abc	< 0.01
DBP (mmHg)	83.54 ± 9.22	81.19 ± 9.14	83.50 ± 8.86^a	84.43 ± 9.21^ab	85.06 ± 9.20^abc	< 0.01
HDL-C (mmol/L)	1.54 ± 0.32	1.59 ± 0.32	1.55 ± 0.30^a	1.53 ± 0.32^ab	1.49 ± 0.33^abc	< 0.01
LDL-C (mmol/L)	2.49 ± 0.64	2.33 ± 0.64	2.49 ± 0.60^a	2.54 ± 0.62^ab	2.62 ± 0.64^abc	< 0.01
FBG (mmol/L)	5.54 ± 1.38	5.09 ± 0.68	5.35 ± 0.96^a	5.58 ± 1.31^ab	6.15 ± 1.99^abc	< 0.01
TG (mmol/L)	1.34 (0.98–1.96)	0.97 (0.75–1.25)	1.32 (1.01–1.75)^a	1.45 (1.07–2.19)^ab	1.87 (1.37–2.72)^abc	< 0.01
hs-CRP (mg/L)	1.45 (0.77–2.93)	1.35 (0.67–2.80)	1.34 (0.71–2.69)^a	1.49 (0.80–2.98)^ab	1.64 (0.92–3.19)^abc	< 0.01
TyG index₂₀₀₆	8.64 ± 0.69	8.22 ± 0.53	8.56 ± 0.57^a	8.74 ± 0.65^ab	9.04 ± 0.70^abc	< 0.01
TyG index₂₀₀₈	8.66 ± 0.68	8.19 ± 0.50	8.56 ± 0.51^a	8.76 ± 0.61^ab	9.15 ± 0.69^abc	< 0.01
TyG index₂₀₁₀	8.69 ± 0.67	8.30 ± 0.51	8.61 ± 0.55^a	8.77 ± 0.65^ab	9.09 ± 0.70^abc	< 0.01
Cum-TyG	34.93 ± 1.48	30.05 ± 1.62	33.23 ± 0.70^a	35.88 ± 0.87^ab	40.56 ± 2.61^abc	< 0.01
Current smoking, N (%)	20,711 (38.28)	5314 (39.29)	5465 (40.41)	5111 (37.79)^ab	4821 (35.65^)abc	< 0.01
Current drinker, N (%)	19,167 (35.43)	4789 (35.4)	4952 (36.61)	4769 (35.26)	4657 (34.44)^ab	< 0.01
Physical activity, N (%)	7833.0 (14.48)	1584 (11.71)	1621 (11.99)	2163 (15.99)^ab	2465 (18.23)^abc	< 0.01
Hypertension, N (%)	25,880 (47.84)	4649 (34.38)	6062 (44.82)^a	7115 (52.61)^ab	8054 (59.55)^abc	< 0.01
Diabetes mellitus, N (%)	6022 (11.13)	470 (3.48)	930 (6.88)^a	1605 (11.87)^ab	3017 (22.31)^abc	< 0.01
Antihypertensive drugs, N (%)	8397 (15.5)	1354 (10.01)	2007 (14.84)^a	2371 (17.53)^ab	2665 (19.71)^abc	< 0.01
Hypoglycemic drugs, N (%)	3125 (5.78)	239 (1.77)	453 (3.35)^a	772 (5.71)^ab	1661 (12.3)^abc	< 0.01
Lipid-lowering drugs, N (%)	905 (1.67)	123 (0.91)	163 (1.21)^a	226 (1.67)^ab	393 (2.91)^abc	< 0.01

P, comparison of baseline characteristics between different TyG index groups
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FBG fasting blood glucose, TG triglyceride, hs-CRP high-sensitivity C reactive protein, TyG index triglyceride-glucose index
^aP < 0.05, compare with Q1 group. ^bP < 0.05, compare with Q2 group. ^cP < 0.05, compare with Q3 group

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