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Table 4 Laboratory data and biomarkers in patients with SGLT2-I versus patients with other OAD agents alone

From: Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry

 

Total

(N = 583)

SGLT2-I

users

(N = 98)

Non-SGLT-I

users

(N = 485)

p value

Hospital Admission

 WBC, 109/L

9.7 [8.1–12.8]

9 [8.1–10.8]

10 [8.1–13.1]

0.006

 Neutrophils, 109/L

6.8 [5.3–9.4]

6 [5.3–7.5]

7.1 [5.3–9.8]

0.001

 Lymphocytes, 109/L

1.8 [1.3–2.6]

2.2 [1.5–2.9]

1.7 [1.3–2.5]

0.001

 PLTs, count x 109 per L

241 [187–290]

230 [178–292]

243 [189–291]

0.207

 NLR

3.6 [2.4–5.9]

2.9 [1.9–4.1]

3.9 [2.5–6.5]

< 0.001

 PLR

126.2 [91.5–175.8]

102.5 [77.7–143.2]

132.1 [95–182.3]

< 0.001

 NPR

0.03 ± 0.02

0.03 ± 0.01

0.03 ± 0.02

0.03

 CPR, mg/dL

3.9 ± 12.6

3.1 ± 3.8

4 ± 13.8

< 0.001

 Adm. Creatinine, mg/dL

1.2 ± 0.9

1.03 ± 0.3

1.2 ± 0.9

0.016

 HbA1c, mmol/L

50 [46–58]

52 [48–56]

50 [44–59]

0.583

 Admission Glycemia, mg/dl

180 [144–240]

156 [139–200]

187 [147–247]

0.006

 BNP, pg/ml

378 [118–1015]

235 [85–452]

474 [129–1306]

< 0.001

After 24 h

 WBC, N/µl

9.5 [7.9–12]

9.2 [8.1–10.4]

9.5 [7.9–12.3]

0.201

 Neutrophils, 109/L

6.7 [5.4–9.1]

6.2 [5.5–7.3]

7 [5.3–9.6]

0.03

 Lymphocytes, 109/L

1.7 [1.2–2.4]

2 [1.4–3.1]

1.7 [1.2–2.3]

0.001

 NLR

3.8 [2.5–6]

3 [1.9–4.6]

4 [2.7–6.6]

< 0.001

 CPR, mg/dL

9 ± 21

3.3 ± 4.4

11 ± 23.5

0.040

Hospital Discharge

 WBC, N/µl

8.5 [7–9.8]

8.6 [7.4–9.5]

8.4 [6.9–9.8]

0.587

 CPR, mg/dL

8 ± 24.3

3.1 ± 3.7

9.9 ± 28.5

0.01

  1. Continuous variables are presented as median (IQR) while categorical ones as n (%). WBC:   White blood cell; PLTs: Platelets; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; NPR: Neutrophil-to-platelet ratio; CRP:  C-reactive protein