Table 1 Baseline characteristics according to quartiles of TyG index
| Â | TyG index | Â | P | |||
|---|---|---|---|---|---|---|
Characteristics | Total |  < 8.28 | 8.28–8.69 | 8.69–9.19 |  ≥ 9.19 | trend |
Demographic | ||||||
 Age, year | 68.8 ± 12.2 | 71.6 ± 12.9 | 69.8 ± 11.8 | 68.2 ± 11.8 | 65.5 ± 11.7 |  < 0.0001 |
 Male sex | 915 (60.1) | 240 (63.2) | 229 (60.0) | 225 (58.6) | 221 (58.6) | 0.53 |
 Current cigarette smoking | 324 (21.3) | 83 (21.8) | 73 (19.1) | 88 (22.9) | 80 (21.2) | 0.62 |
 Current alcohol drinking | 152 (10.0) | 36 (9.5) | 32 (8.4) | 42 (10.9) | 42 (11.1) | 0.54 |
Clinical features | ||||||
 Time from onset to randomization, h | 24.0 (6.0–69.7) | 24.0 (5.0–48.0) | 24.0 (6.0–72.0) | 24.0 (7.0–48.0) | 24.0 (7.0–72.0) | 0.005 |
 Baseline SBP, mmHg | 152.2 ± 22.1 | 149.7 ± 23.7 | 152.6 ± 21.0 | 153.5 ± 22.0 | 152.8 ± 21.5 | 0.047 |
 Baseline DBP, mmHg | 85.3 ± 12.5 | 83.5 ± 13.0 | 85.5 ± 12.2 | 85.9 ± 12.6 | 86.2 ± 11.9 | 0.003 |
 Triglyceride, mmol/L | 1.3 (0.9–1.8) | 0.7 (0.6–0.9) | 1.1 (1.0–1.3) | 1.5 (1.3–1.8) | 2.4 (1.7–3.2) |  < 0.0001 |
 Total cholesterol, mmol/L | 4.6 (3.9–5.3) | 4.3 (3.5–4.9) | 4.5 (3.9–5.2) | 4.7 (4.1–5.4) | 5.1 (4.2–5.9) |  < 0.0001 |
 LDL cholesterol, mmol/L | 2.7 (2.2–3.4) | 2.4 (1.9–2.9) | 2.7 (2.2–3.3) | 2.9 (2.3–3.5) | 2.9 (2.4–3.6) |  < 0.0001 |
 HDL cholesterol, mmol/L | 1.2 (1.0–1.4) | 1.3 (1.1–1.5) | 1.2 (1.0–1.4) | 1.1 (1.0–1.3) | 1.0 (0.9–1.2) |  < 0.0001 |
 Plasma glucose, mmol/L | 6.8 ± 3.7 | 5.0 ± 0.9 | 5.7 ± 1.2 | 6.4 ± 1.6 | 10.0 ± 6.1 |  < 0.0001 |
 White blood cell count, 109/L | 6.6 (5.4–8.2) | 6.3 (5.0–7.8) | 6.6 (5.4–8.2) | 6.8 (5.7–8.3) | 6.9 (5.8–8.5) | 0.01 |
 Admission NIHSS score | 3.0 (2.0–6.0) | 4.0 (2.0–7.0) | 3.0 (2.0–5.0) | 3.0 (2.0–6.0) | 3.0 (2.0–5.0) | 0.17 |
Medical history | ||||||
 Hypertension | 1215 (79.8) | 272 (71.6) | 310 (81.2) | 311 (81.0) | 322 (85.4) |  < 0.0001 |
 Diabetes | 397 (26.1) | 26 (6.8) | 53 (13.9) | 98 (25.5) | 220 (58.4) |  < 0.0001 |
 Coronary heart disease | 70 (4.6) | 16 (4.2) | 12 (3.1) | 21 (5.5) | 21 (5.6) | 0.33 |
 Atrial fibrillation | 196 (12.9) | 83 (21.8) | 54 (14.1) | 30 (7.8) | 29 (7.7 ) |  < 0.0001 |
 Stroke | 1201 (78.9) | 293 (77.1) | 304 (79.6) | 306 (79.7) | 298 (79.1) | 0.8 |
Medication history | Â | Â | Â | Â | Â | |
 Antihypertensive | 895 (58.8) | 191 (50.3) | 228 (59.7) | 239 (62.2) | 237 (62.9) | 0.001 |
 Lipid-lowering | 46 (3.0) | 17 (4.5) | 9 (2.4) | 14 (3.7) | 6 (1.6) | 0.09 |
Stroke syndrome | ||||||
 TACS | 82 (5.4) | 29 (7.6) | 17 (4.5) | 14 (3.7) | 22 (5.8) | 0.08 |
 PACS | 798 (52.4) | 215 (56.6) | 197 (51.6) | 204 (53.1) | 182 (48.3) | 0.14 |
 POCS | 379 (24.9) | 65 (17.1) | 89 (23.3) | 108 (28.1) | 117 (31.0) |  < 0.0001 |
 LACS | 264 (17.3) | 71 (18.7) | 79 (20.7) | 58 (15.1) | 56 (14.9) | 0.09 |
Ischemic stroke subtype | ||||||
 Large-artery atherosclerosis | 949 (62.3) | 193 (50.8) | 225 (58.9) | 253 (65.9) | 278 (73.7) |  < 0.0001 |
 Cardioembolism | 254 (16.7) | 107 (28.2) | 66 (17.3) | 44 (11.5) | 37 (9.8) |  < 0.0001 |
 Lacunar | 215 (14.1) | 50 (13.2) | 67 (17.5) | 54 (14.1) | 44 (11.7) | 0.12 |
 Other | 105 (6.9) | 30 (7.9) | 24 (6.3) | 33 (8.6) | 18 (4.8) | 0.16 |