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Table 4 Changes in cardiovascular disease risk factors of males following intensive lifestyle intervention

From: Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial

 

High-FMI

Low-FMI

High-FMI vs

Low-FMI, p-value

High-ASMI vs

Low-ASMI,

p-value

FMI by ASMI interaction,

p-value

 

High-ASMI (n = 72)

Low-ASMI (n = 184)

High-ASMI (n = 184)

Low-ASMI

(n = 71)

Body mass, kg

− 9.5 (8.1)

− 12.0 (8.3)

− 8.8 (5.7)

− 9.0 (7.1)

0.097

0.041

0.557

BMI, kg/m2

− 3.0 (2.7)

− 4.0 (2.7)

− 2.8 (1.8)

− 3.1 (2.4)

0.104

0.012

0.612

A1C, mmol/mol

− 34.4 (13.6)

− 31.1 (13.9)

− 31.1 (9.5)

− 27.9 (9.5)

0.038

0.095

0.824

A1C, %

− 1.0 (1.2)

− 0.7 (1.3)

− 0.7 (0.9)

− 0.4 (0.9)

0.038

0.095

0.824

Fasting blood glucose, mg/dL

− 40.2 (47.5)

− 27.4 (57.9)

− 17.2 (43.3)

− 15.3 (34.9)

0.008

0.393

0.334

HDL-C, mg/dL

5.4 (5.2)

3.7 (6.8)

4.7 (7.6)

4.6 (7.3)

0.966

0.333

0.309

LDL-C, mg/dL

− 6.7 (25.0)

− 5.7 (24.7)

− 6.0 (25.7)

− 3.4 (31.7)

0.668

0.391

0.758

Triglycerides, mg/dL

− 59.4 (133.3)

− 65.0 (142.1)

− 33.0 (167.1)

− 47.4 (87.0)

0.240

0.553

0.758

Systolic blood pressure, mmHg

− 5 (18.0)

− 10 (18)

− 8 (16)

− 5 (14)

0.845

0.591

0.212

Diastolic blood pressure, mmHg

− 4 (7)

− 3 (8)

− 4 (9)

− 3 (7)

0.934

0.167

0.727

Cardiorespiratory fitness, MET

2.4 (2.1)

1.9 (2.2)

1.5 (2.8)

2.3 (2.7)

0.607

0.436

0.058

Depression, point

− 1.8 (4.7)

− 2.0 (4.5)

− 0.6 (4.9)

− 2.1 (4.4)

0.150

0.670

0.358

HR-QoL (PCS), point

− 0.2 (12.4)

3.8 (7.2)

1.9 (6.1)

2.9 (7.6)

0.862

0.058

0.112

HR-QoL (MCS), point

5.2 (9.4)

1.2 (9.5)

0.1 (6.6)

3.5 (6.5)

0.113

0.236

0.003

  1. Data are reported mean (SD). Values in boldface represent statistical significance (p < 0.05)
  2. ASMI appendicular skeletal muscle mass index, A1C glycated hemoglobin A1C, BMI body mass index, HR-QoL health-related quality of life, MCS mental component summary, MET metabolic equivalent, PCS physical component summary