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Table 3 Changes in cardiovascular disease risk factors of females following intensive lifestyle intervention

From: Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial

 

High-FMI

Low-FMI

High-FMI vs

Low-FMI, p-value

High-ASMI vs

Low-ASMI, p-value

FMI by ASMI interaction,

p-value

 

High-ASMI (n = 157)

Low-ASMI (n = 272)

High-ASMI (n = 272)

Low-ASMI (n = 156)

Body mass, kg

− 9.2 (6.7)

− 9.9 (6.0)

− 6.7 (5.8)

− 6.1 (4.7)

 < 0.001

0.698

0.304

BMI, kg/m2

− 3.4 (2.5)

− 4.0 (2.4)

− 2.6 (1.1)

− 2.6 (2.0)

 < 0.001

0.609

0.203

A1C, mmol/mol

− 27.4 (10.3)

− 30.5 (10.8)

− 29.5 (10.7)

− 32.5 (12.6)

0.275

0.097

0.937

A1C, %

− 0.36 (0.9)

− 0.65 (1.0)

− 0.55 (1.0)

− 0.82 (1.2)

0.275

0.097

0.937

Fasting blood glucose, mg/dL

− 14.9 (45.3)

− 31.0 (49.8)

− 24.5 (33.8)

− 26.7 (55.3)

0.622

0.669

0.165

HDL-C, mg/dL

3.6 (7.9)

2.5 (6.9)

4.4 (8.5)

4.0 (6.9)

0.472

0.137

0.761

LDL-C, mg/dL

− 5.9 (31.1)

− 3.3 (29.5)

− 1.7 (25.3)

− 2.3 (37.4)

0.896

0.594

0.467

Triglycerides, mg/dL

− 30.6 (143.9)

− 22.8 (85.2)

− 27.5 (76.2)

− 26.7 (97.0)

0.828

0.659

0.441

Systolic blood pressure, mmHg

− 9 (19)

− 11 (18)

− 5 (17)

− 7 (15)

0.183

0.045

0.907

Diastolic blood pressure, mmHg

− 3 (9)

− 4 (9)

− 2 (8)

− 2 (8)

0.448

0.251

0.321

Cardiorespiratory fitness, MET

1.6 (1.8)

1.4 (1.8)

1.8 (2.5)

1.4 (2.5)

0.755

0.264

0.596

Depression, point

− 3.1 (5.1)

− 2.6 (5.4)

− 1.4 (5.1)

− 1.4 (4.4)

0.027

0.576

0.638

HR-QoL (PCS), point

3.1 (7.0)

2.5 (9.7)

0.7 (6.8)

3.2 (7.5)

0.770

0.977

0.050

HR-QoL (MCS), point

0.6 (10.4)

1.2 (10.6)

1.4 (10.0)

1.2 (7.4)

0.793

0.526

0.772

  1. Data are reported mean (SD). Values in boldface represent statistical significance (p < 0.05)
  2. ASMI appendicular skeletal muscle mass index, A1C glycated hemoglobin A1C, BMI body mass index, FMI fat mass index, HR-QoL health-related quality of life, MCS mental component summary, MET metabolic equivalent, PCS physical component summary