Relative contributions of statin intensity, achieved low-density lipoprotein cholesterol level, and statin therapy duration to cardiovascular risk reduction in patients with type 2 diabetes: population based cohort study

Table 2 Cumulative incidence of major cardiovascular events by statin intensity

	Low-intensity group	Moderate- or high-intensity group	P-value†
	(n = 383)	(n = 8554)	P-value†
MACE
No. of events	48	813
Incidence rate*	3.76	2.69
HR (95% CI)	1 (reference)	0.72 (0.54–0.96)	0.027
Ischemic heart disease
No. of events	30	492
Incidence rate*	0.1	1.6
HR (95% CI)	1 (reference)	0.70 (0.49–1.01)	0.056
Ischemic stroke
No. of events	17	293
Incidence rate*	1.26	0.94
HR (95% CI)	1 (reference)	0.75 (0.46–1.22)	0.240
Cardiovascular death
No. of events	5	94
Incidence rate*	0.36	0.3
HR (95% CI)	1 (reference)	0.82 (0.33–2.01)	0.659

^*Incidence rate per 100 person-years
^†P value by Cox proportional hazards model with robust variance estimator for clustered data
HR: hazard ratio; CI: confidence interval; MACE: major adverse cardiovascular event

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