Fig. 6

Ingenuity Pathway Analysis (IPA) of the differentially expressed angiogenic factors. The top panel shows data analysis of all compared study groups. The middle panel shows comparisons of healthy controls against all T2D patients compiled (with and without CAD), and the bottom panel shows comparisons between healthy T2D and the ones with CAD compiled. A, D, G Top networks and associated diseases/functions, with scores and associated molecules, obtained from IPA. B, E, H Representation of the most highly rated network in IPA. Highlighted are the differentially expressed molecules and relationships where the interaction is direct. C, F, I IPA prediction of the interactive network associated with the differentially expressed proteins in relation to CAD and their effect on endothelial function. Green: decreased measurement, blue: predicted inhibition, Orange: predicted activation. Straight-line: direct interaction, segmented line: indirect relationship. Data was generated by QIAGEN’s Ingenuity ® Pathway Analysis application (www.qiagen.com/ingenuity)