Table 2 Association between diabetes and the risk of lower extremity amputation for chronic limb-threatening ischemia: Cox proportional hazards regression analysis
Characteristics | Person-years | Cases | HR (95% CI)a | HR (95% CI)b |
|---|---|---|---|---|
All subjects | ||||
 No diabetes | 1,106,992 | 310 | 1.00 | 1.00 |
 Diabetes | 82,938 | 346 | 13.61 (11.64–15.91) | 13.41 (11.38–15.79) |
 Diabetes < 5 years | 35,685 | 96 | 9.12 (7.25–11.48) | 8.95 (7.07–11.32) |
 Diabetes 5 to < 10 years | 21,057 | 71 | 11.33 (8.74–14.69) | 11.13 (8.55–14.49) |
 Diabetes 10− < 15 years | 14,143 | 88 | 19.98 (15.71–25.42) | 19.66 (15.38–25.12) |
 Diabetes 15+ years | 12,053 | 91 | 23.67 (18.6–30.13) | 23.22 (18.16–29.67) |
 P for trend |  |  |  < 0.0001 |  < 0.0001 |
Men | ||||
 No diabetes | 464,606 | 162 | 1.00 | 1.00 |
 Diabetes | 32,863 | 156 | 13.78 (11.03–17.23) | 13.78 (10.91–17.44) |
 Diabetes < 5 years | 13,933 | 41 | 8.50 (6.03–11.98) | 8.57 (6.03–12.18) |
 Diabetes 5 to < 10 years | 8383 | 33 | 11.96 (8.22–17.41) | 11.96 (8.15–17.55) |
 Diabetes 10− < 15 years | 5517 | 39 | 20.65 (14.48–29.44) | 20.22 (14.08–29.04) |
 Diabetes 15+ years | 5030 | 43 | 25.82 (18.26–36.53) | 25.58 (17.94–36.47) |
 P for trend |  |  |  < 0.0001 |  < 0.0001 |
Women | ||||
 No diabetes | 642,386 | 148 | 1.00 | 1.00 |
 Diabetes | 50,075 | 190 | 13.14 (10.54–16.38) | 12.58 (9.96–15.77) |
 Diabetes < 5 years | 21,752 | 55 | 9.45 (6.92–12.91) | 8.92 (6.48–12.28) |
 Diabetes 5 to < 10 years | 12,675 | 38 | 10.52 (7.34–15.07) | 10.02 (6.96–14.43) |
 Diabetes 10− < 15 years | 8626 | 49 | 19.00 (13.67–25.42) | 18.25 (13.05–25.52) |
 Diabetes 15+ years | 7022 | 48 | 21.48 (15.35–30.06) | 20.23 (14.37–28.48) |
 P for trend |  |  |  < 0.0001 |  < 0.0001 |