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Table 3 Sensitivity and interaction analyses between liver transient elastography parameters and selected clinical characteristics for total cardiovascular events and all-cause mortality outcomes

From: Prognostic impact of liver fibrosis and steatosis by transient elastography for cardiovascular and mortality outcomes in individuals with nonalcoholic fatty liver disease and type 2 diabetes: the Rio de Janeiro Cohort Study

 

Total Cardiovascular Events (n = 69)

All-cause Mortality (n = 85)

 

LSM

CAP

LSM

CAP

Characteristic

HR (95 %CI)

Pinteraction

HR (95 %CI)

Pinteraction

HR (95 %CI)

Pinteraction

HR (95 %CI)

Pinteraction

Age < 65 years (n = 191)

1.00 (0.94–1.07)

0.85

0.91 (0.84–0.99)*

0.78

1.01 (0.95–1.07)

0.59

0.88 (0.80–0.96)*

0.71

≥65 years (n = 209)

1.05 (1.00–1.10)*

 

0.97 (0.90–1.04)

 

1.04 (1.00–1.08)

 

0.95 (0.89–1.00)

 

Female sex (n = 236)

1.04 (0.99–1.09)

0.60

0.96 (0.90–1.02)

0.18

1.04 (0.99–1.09)

0.83

0.89 (0.84–0.95)*

0.20

Male sex (n = 144)

1.03 (0.98–1.09)

 

0.95 (0.87–1.03)

 

1.04 (1.00–1.07)

 

0.98 (0.91–1.06)

 

Non-obese (n = 198)

1.05 (0.98–1.11)

0.92

0.96 (0.89–1.03)

0.66

1.05 (1.01–1.09)*

0.52

0.95 (0.89–1.01)

0.56

Obese (n = 202)

1.04 (0.99–1.08)

 

0.93 (0.86-1.00)*

 

1.03 (0.98–1.07)

 

0.89 (0.83–0.96)*

 

Never smokers (n = 228)

1.01 (0.94–1.08)

0.21

0.99 (0.92–1.06)

0.20

1.02 (0.95–1.08)

0.33

0.98 (0.92–1.04)

0.044

Current/past smokers (n = 172)

1.05 (1.01–1.09)*

 

0.87 (0.80–0.95)*

 

1.04 (1.01–1.07)*

 

0.88 (0.82–0.94)*

 

Without CVD (n = 293)

1.04 (0.98–1.09)

0.72

0.94 (0.88–1.01)

0.88

1.04 (1.00-1.08)*

0.80

0.91 (0.86–0.97)*

0.14

With CVD (n = 107)

1.05 (0.99–1.11)

 

0.93 (0.86-1.00)

 

1.03 (0.96–1.09)

 

0.92 (0.86-1.00)*

 

Without microvasc (n = 204)

1.04 (0.98–1.10)

0.72

0.91 (0.84–0.99)*

0.77

1.04 (1.01–1.08)*

0.34

0.89 (0.83–0.97)*

0.10

With microvasc (n = 196)

1.02 (0.96–1.09)

 

0.96 (0.89–1.03)

 

1.02 (0.97–1.08)

 

0.94 (0.88–1.00)

 
  1. Values are hazard ratios (95% confidence intervals) estimated for increments of 1 kPa in LSM and 10 dB/m in CAP, and adjusted for the same covariates as in model 1 from Table 2, except the respective stratifying variable
  2. LSM liver stiffness measurement, CAP controlled attenuation parameter, HR hazard ratio, CI confidence interval, microvasc microvascular complications
  3. *p < 0.05