Fig. 2

The results of the major CV outcomes trials on patients with SGLT-2i are presented according to the ascending gain in months free of HHF since the beginning of the study (upper panels) for each 100 patients enrolled in the study. The continuous line is calculated from the original Kaplan Majer curves, the dotted line is the best fit calculated from the more robust part of the study (i.e., until at least 50% of the subjects are in the follow-up) then extrapolated to 72 months. In the lower panels data are expressed as NNT that is necessary to gain 1 year free of HHF (NNT/Y⁺) as a function of time