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Table 1 Demographic characteristics, comorbidities and in-hospital admission findings of MIOCA and MINOCA ACS patients, according to admission hyperglycemia

From: Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA

 

MIOCA

N = 2198

MINOCA

N = 233

HGL MIOCA vs MINOCA

no-aHGL

N = 1321

aHGL

N = 877

p-value

no-aHGL

N = 195

aHGL

N = 38

p-value

p-value

Age, years, median [IQR]

69 [58–78]

73 [63–81]

< 0.001

68 [53–77]

74 [67–81]

< 0.001

ns

Gender Female, n (%)

341 (25.8)

262 (30)

0.037

126 (64.6)

26 (68.4)

ns

< 0.001

BMI kg/m2, median [IQR]

26.2 [24–29.3]

27 [24.3–30.1]

0.001

25.7 [22.5–28.5]

26 [23.1–29.3]

0.001

ns

Cardiovascular risk factors

 Current/past smoking, n (%)

812 (61.5)

482 (55)

0.002

87 (44.6)

13 (34.2)

ns

0.0012

 Hypertension, n (%)

855 (67)

654 (74.6)

< 0.001

126 (64.6)

29 (76.3)

ns

ns

 Dyslipidemia, n (%)

814 (61.6)

531 (60.5)

ns

123 (63.1)

19 (50)

ns

ns

 Type-2 diabetes, n (%)

118 (9)

458 (52.2)

< 0.001

13 (6.7)

15 (39.5)

< 0.001

ns

 De novo Type-2 diabetes, n (%)

7 (0.6)

31 (7)

< 0.001

2 (1.1)

3 (13)

< 0.001

ns

Medical history

 Previous AMI, n (%)

268 (20.4)

216 (24.7)

0.016

18 (10)

2 (5.7)

ns

0.001

 Previous stroke, n (%)

72 (5.5)

72 (8.2)

0.01

10 (5.1)

2 (5.3)

ns

ns

 COPD, n (%)

138 (10.5)

115 (13.1)

ns

21 (10.8)

5 (13.2)

ns

ns

 CKD, n (%)

298 (23.1)

334 (39)

< 0.001

36 (18.8)

14 (37.8)

0.011

ns

 PAD, n (%)

81 (6.1)

93 (10.6)

< 0.001

4 (2.1)

2 (5.3)

ns

ns

Hospital admission

 Angina, n (%)

1008 (76.5)

589 (68)

< 0.001

133 (68.6)

13 (34.2)

< 0.001

< 0.001

 HR, median [IQR]

72 [61–86]

81 [69–99]

< 0.001

72 [63–88]

97 [72–118]

< 0.001

0.019

 SBP, median [IQR]

140 [120–160]

140 [120–160]

ns

140 [120–155]

140 [120–160]

ns

ns

 DBP, median [IQR]

80 [70–90]

80 [70–90]

ns

80 [70–90]

80 [70–85]

ns

ns

 Atrial fibrillation, n (%)

86 (6.6)

97 (11.1)

< 0.001

14 (7.2)

12 (31.6)

< 0.001

< 0.001

 STEMI, n (%)

571 (43.2)

416 (47.4)

ns

22 (11.3)

5 (13.2)

ns

< 0.001

 PCI total, n (%)

1113 (84.3)

751 (85.6)

0.38

/

/

 

/

 PCI/NSTEMI, n (%)

601/750 (80.1)

366/461 (79.4)

0.76

/

/

 

/

 Killip class III/IV, n (%)

31 (2.4)

116 (13.3)

< 0.001

3 (1.6)

4 (10.8)

0.003

ns

 LVEDV, mL median [IQR]

100 [83–121]

108 [85–135]

0.004

90 [74–107]

82 [70–122]

ns

0.023

 LV EF %, median [IQR]

55 [45–60]

46 [40–56]

< 0.001

60 [53–62]

60 [50–62]

ns

< 0.001

 Peak hs Troponin I ng/L, median [IQR]

2751 [545–17182]

6334 [999–34431]

< 0.001

461 [109–1691]

370 [136–777]

ns

< 0.001

 aBGL level mg/dL, median [IQR]

110 [99–122]

180 [155–234]

< 0.001

104 [93–116]

187 [157–228]

< 0.001

ns

 Creatinine, median [IQR]

0.9 [0.8–1.1]

1 [0.9–1.3]

< 0.001

0.8 [0.7–1]

1 [0.77–1.2]

0.017

0.038

 eGFR_CKDEPI, median [IQR]

78 [61–91]

67 [49–84]

< 0.001

85 [63–98]

67 [54–79]

< 0.001

ns

 BNP pg/mL, median [IQR]

367 [154–723]

514 [192–957]

0.033

159 [72–357]

707 [354–1370]

< 0.008

ns

GRACE score, median [IQR]

136 [115–159]

153 [129–180]

< 0.001

122 [99–144]

154 [128–181]

< 0.001

ns

  1. Continuous variables are presented as median (IQR) while categorical ones as n (%)
  2. no-aHGL admission normal glucose level, aHGL admission high glucose level, BMI body max index, AMI acute myocardial infarction, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, PAD peripheral artery disease, HR heart rate, SBP systolic blood pressure, DBP diastolic blood pressure, STEMI ST-segment elevation myocardial infarction, NSTEMI non-ST segment elevation myocardial infarction, PCI percutaneous coronary intervention, LVEDV left-ventricular-end-diastolic-volume, LVEF left ventricular ejection fraction, aBGL admission blood glucose level
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Cardiovascular Diabetology

ISSN: 1475-2840