The association of hepatic steatosis and fibrosis with heart failure and mortality

Table 2 Hazard ratios and 95% confidence intervals for incident heart failure, hospitalization for heart failure, all-cause mortality, and cardiovascular mortality according to FLI score in the general population

	Model 1				Model 2			Model 3			Model 4
	Events (n)	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
iHF
FLI < 20	11,247	Ref.			Ref.			Ref.			Ref.
20 ≤ FLI < 60	13,146	1.850	1.804–1.897	< 0.001	1.303	1.266–1.342	< 0.001	1.289	1.252–1.328	< 0.001	1.123	1.090–1.157	< 0.001
FLI ≥ 60	4131	2.255	2.176–2.337	< 0.001	1.715	1.683–1.795	< 0.001	1.670	1.595–1.749	< 0.001	1.300	1.240–1.362	< 0.001
hHF
FLI < 20	5060	Ref.			Ref.			Ref.			Ref.
20 ≤ FLI < 60	5630	1.738	1.673–1.805	< 0.001	1.334	1.276–1.394	< 0.001	1.305	1.249–1.364	< 0.001	1.160	1.109–1.213	< 0.001
FLI ≥ 60	1794	2.156	2.043–2.275	< 0.001	2.041	1.906–2.186	< 0.001	1.936	1.806–2.075	< 0.001	1.542	1.438–1.655	< 0.001
All-cause mortality
FLI < 20	11,857	Ref.			Ref.			Ref.			Ref.
20 ≤ FLI < 60	10,752	1.418	1.381–1.455	< 0.001	1.247	1.210–1.286	< 0.001	1.211	1.178–1.249	< 0.001	1.133	1.908–1.168	< 0.001
FLI ≥ 60	3058	1.557	1.496–1.620	< 0.001	1.992	1.897–2.091	< 0.001	1.858	1.768–1.952	< 0.001	1.619	1.540–1.702	< 0.001
CV mortality
FLI < 20	1359	Ref.			Ref.			Ref.			Ref.
20 ≤ FLI < 60	1351	1.554	1.442–1.676	< 0.001	1.326	1.214–1.447	< 0.001	1.287	1.178–1.405	< 0.001	1.105	1.011–1.207	0.028
FLI ≥ 60	364	1.616	1.440–1.814	< 0.001	2.015	1.748–2.323	< 0.001	1.871	1.620–2.160	< 0.001	1.413	1.221–1.634	< 0.001

CI confidence interval, CV cardiovascular, HR hazard ratio, iHF incident heart failure, hHF incident hospitalized heart failure
Model 1: crude
Model 2: age, sex and body weight
Model 3: model 2 + alcohol drinking, smoking, regular exercise, and income status
Model 4: model 3 + hypertension, diabetes mellitus, dyslipidemia, and estimated glomerular filtration rate

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