Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus

Table 2 Unadjusted and adjusted hazard ratio of the association of sex with cardiovascular mortality^a stratified by type 2 diabetes mellitus status (n = 7443)

	No type 2 diabetes mellitus (n = 6988)		Type 2 diabetes mellitus (n = 455)
	Hazard ratio (95%-CI)	p-value	Hazard ratio (95%-CI)	p-value
Model 1
Men versus women	1.88 (1.58; 2.24)	< 0.001	1.28 (0.89; 1.83)	0.178
Model 2
Men versus women	1.94 (1.62; 2.31)	< 0.001	1.41 (0.97; 2.04)	0.070
Age (years)	1.15 (1.14; 1.16)	< 0.001	1.12 (1.09; 1.15)	< 0.001
Body mass index (kg/m²)	1.06 (1.04; 1.08)	< 0.001	1.00 (0.96; 1.04)	0.919
Low-density lipoprotein cholesterol (mmol/L)	1.05 (0.96; 1.14)	0.315	1.02 (0.85; 1.25)	0.773
Fasting status	1.28 (0.87; 1.88)	0.218	2.19 (0.68; 7.06)	0.191
Model 3
Men versus women	1.94 (1.63; 2.32)	< 0.001	1.53 (1.04; 2.24)	0.029
Age (years)	1.15 (1.14; 1.16)	< 0.001	1.12 (1.09; 1.15)	< 0.001
Body mass index (kg/m²)	1.06 (1.04; 1.08)	< 0.001	1.00 (0.96; 1.04)	0.950
Low-density lipoprotein cholesterol (mmol/L)	1.04 (0.95; 1.14)	0.377	1.02 (0.84; 1.24)	0.840
Fasting status	1.27 (0.86; 1.88)	0.227	2.32 (0.72; 0.75)	0.161
Lipoprotein(a) (100 mg/L)	1.01 (0.98; 1.05)	0.553	1.07 (1.01; 1.12)	0.012

Data are reported as hazard ratios (95% confidence intervals [CI]) and p-values derived from Cox regression models. All models (including model 1) were also adjusted for study sample
^aCardiovascular mortality = ICD-10 codes: I10 to I79 in SHIP-0 and I10 to I99 in MONICA/KORA S3

ISSN: 1475-2840