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Table 2 Odds ratio of the proteins which are significantly associated with diabetes after adjustment for age, sex, hypertension, BMI, CAD and eGFR

From: Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial

Protein Abbreviation Odds ratio (95% CI) p-value FDRq
Positive association (n = 21)
 Interleukin-1 receptor type 1 il1rt1 4.52 (2.41–8.5) 0.00001 0.0005
 Cathepsin d ctsd 3.49 (2.13–5.72) 0.00001 0.0005
 Growth differentiation factor 15 gdf15 3.41 (2.39–4.87) 0.00001 0.0005
 Galectin-4 gal4 2.95 (1.95–4.45) 0.00001 0.0005
 E-selectin sele 2.38 (1.64–3.45) 0.00001 0.0005
 Eotaxin ccl11 2.96 (1.79–4.9) 0.00002 0.0009
 Leukemia inhibitory factor receptor lifr 4.4 (2.15–9.04) 0.00005 0.0017
 Kidney injury molecule kim1 1.79 (1.35–2.38) 0.00005 0.0017
 Cathepsin z ctsz 3.1 (1.78–5.41) 0.00007 0.0019
 Hydroxyacid oxidase 1 haox1 1.44 (1.2–1.72) 0.00007 0.0019
 P-selectin glycoprotein ligand 1 psgl1 4.23 (1.95–9.16) 0.00026 0.0054
 Interleukin-18 receptor 1 il18r1 2.35 (1.43–3.87) 0.00074 0.014
 Prostasin prss8 2.97 (1.55–5.69) 0.00102 0.0173
 C–C motif chemokine 15 ccl15 2.13 (1.34–3.38) 0.00135 0.0215
 Interleukin-10 il10 1.74 (1.23–2.45) 0.00168 0.024
 Gastric intrinsic factor gif 1.34 (1.11–1.6) 0.00196 0.0253
 Matrix metalloprotease 7 mmp7 1.92 (1.27–2.9) 0.00187 0.0253
 Granulin grn 2.66 (1.42–5) 0.00237 0.0292
 Follistatin fs 2.16 (1.29–3.61) 0.00333 0.0392
 Alpha-l-iduronidase idua 2.04 (1.26–3.29) 0.0036 0.0407
 Osteoprotegerin opg 2.43 (1.32–4.45) 0.00422 0.044
Negative association (n = 5)
 Collagen type 1 alpha 1 col1a1 0.33 (0.19–0.58) 0.00013 0.003
 Procollagen type 1 carboxy-terminal propeptide picp 0.36 (0.22–0.62) 0.00016 0.0036
 Lipoprotein lipase lpl 0.48 (0.31–0.74) 0.00085 0.0154
 Matrix extracellular phosphoglycoprotein mepe 0.43 (0.26–0.73) 0.00167 0.024
 C-X-C motif chemokine 10 cxcl10 0.65 (0.48–0.87) 0.00418 0.044