Table 2 Odds ratio of the proteins which are significantly associated with diabetes after adjustment for age, sex, hypertension, BMI, CAD and eGFR
Protein | Abbreviation | Odds ratio (95% CI) | p-value | FDRq |
|---|---|---|---|---|
Positive association (n = 21) | ||||
Interleukin-1 receptor type 1 | il1rt1 | 4.52 (2.41–8.5) | 0.00001 | 0.0005 |
Cathepsin d | ctsd | 3.49 (2.13–5.72) | 0.00001 | 0.0005 |
Growth differentiation factor 15 | gdf15 | 3.41 (2.39–4.87) | 0.00001 | 0.0005 |
Galectin-4 | gal4 | 2.95 (1.95–4.45) | 0.00001 | 0.0005 |
E-selectin | sele | 2.38 (1.64–3.45) | 0.00001 | 0.0005 |
Eotaxin | ccl11 | 2.96 (1.79–4.9) | 0.00002 | 0.0009 |
Leukemia inhibitory factor receptor | lifr | 4.4 (2.15–9.04) | 0.00005 | 0.0017 |
Kidney injury molecule | kim1 | 1.79 (1.35–2.38) | 0.00005 | 0.0017 |
Cathepsin z | ctsz | 3.1 (1.78–5.41) | 0.00007 | 0.0019 |
Hydroxyacid oxidase 1 | haox1 | 1.44 (1.2–1.72) | 0.00007 | 0.0019 |
P-selectin glycoprotein ligand 1 | psgl1 | 4.23 (1.95–9.16) | 0.00026 | 0.0054 |
Interleukin-18 receptor 1 | il18r1 | 2.35 (1.43–3.87) | 0.00074 | 0.014 |
Prostasin | prss8 | 2.97 (1.55–5.69) | 0.00102 | 0.0173 |
C–C motif chemokine 15 | ccl15 | 2.13 (1.34–3.38) | 0.00135 | 0.0215 |
Interleukin-10 | il10 | 1.74 (1.23–2.45) | 0.00168 | 0.024 |
Gastric intrinsic factor | gif | 1.34 (1.11–1.6) | 0.00196 | 0.0253 |
Matrix metalloprotease 7 | mmp7 | 1.92 (1.27–2.9) | 0.00187 | 0.0253 |
Granulin | grn | 2.66 (1.42–5) | 0.00237 | 0.0292 |
Follistatin | fs | 2.16 (1.29–3.61) | 0.00333 | 0.0392 |
Alpha-l-iduronidase | idua | 2.04 (1.26–3.29) | 0.0036 | 0.0407 |
Osteoprotegerin | opg | 2.43 (1.32–4.45) | 0.00422 | 0.044 |
Negative association (n = 5) | ||||
Collagen type 1 alpha 1 | col1a1 | 0.33 (0.19–0.58) | 0.00013 | 0.003 |
Procollagen type 1 carboxy-terminal propeptide | picp | 0.36 (0.22–0.62) | 0.00016 | 0.0036 |
Lipoprotein lipase | lpl | 0.48 (0.31–0.74) | 0.00085 | 0.0154 |
Matrix extracellular phosphoglycoprotein | mepe | 0.43 (0.26–0.73) | 0.00167 | 0.024 |
C-X-C motif chemokine 10 | cxcl10 | 0.65 (0.48–0.87) | 0.00418 | 0.044 |