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Table 4 Comparison of incremental values between FGF21/adiponectin ratio and the use of FGF21 or adiponectin alone (n = 4797)

From: FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China

 

AUC

95% CI

C statistics

NRI (%)

p value

IDI (%)

p value

C statistics

NRI (%)

p value

IDI (%)

p value

Model 1

0.791

0.756–0.826

Ref.

Ref.

Ref.

Ref.

Ref.

     

 + FGF21/adiponectin ratioa

0.800

0.766–0.833

0.731

27.1

< 0.001

0.7

0.020

Ref.

Ref.

Ref.

Ref.

Ref.

 + FGF21a

0.798

0.765–0.832

0.772

17.4

0.021

0.4

0.101

0.955

− 23.5

0.002

− 0.3

0.014

 + Adiponectina

0.793

0.758–0.828

0.939

23.9

0.001

0.3

0.015

0.789

− 18.3

0.016

− 0.3

0.161

Model 2

0.744

0.708–0.780

Ref.

Ref.

Ref.

Ref.

Ref.

     

 + FGF21/adiponectin ratioa

0.756

0.720–0.791

0.643

32.7

< 0.001

0.6

0.003

Ref.

Ref.

Ref.

Ref.

Ref.

 + FGF21a

0.755

0.720–0.790

0.670

30.6

< 0.001

0.5

0.008

0.967

− 11.9

0.114

− 0.1

0.262

 + Adiponectina

0.746

0.710–0.782

0.924

14.6

0.052

0.1

0.074

0.714

− 31.3

< 0.001

− 0.5

0.007

Model 3

0.818

0.782–0.853

Ref.

Ref.

Ref.

Ref.

Ref.

     

 + FGF21/adiponectin ratioa

0.821

0.785–0.857

0.894

26.9

< 0.001

0.6

0.050

Ref.

Ref.

Ref.

Ref.

Ref.

 + FGF21a

0.821

0.785–0.856

0.897

19.8

0.009

0.4

0.083

0.997

− 14.7

0.051

− 0.1

0.212

 + Adiponectina

0.818

0.782–0.853

0.999

18.9

0.012

0.2

0.088

0.896

− 19.8

0.008

− 0.4

0.100

  1. Model 1 included baseline age, BMI, waist circumference, SBP, triglyceride, HDL-C, LDL-C, hsCRP, sex, HOMA-IR, FPG
  2. Model 2 included baseline age, BMI, waist circumference, SBP, triglyceride, HDL-C, LDL-C, hsCRP, sex, HOMA-IR, 2hPG
  3. Model 3 included baseline age, BMI, waist circumference, SBP, triglyceride, HDL-C, LDL-C, hsCRP, sex, HOMA-IR, HbA1c
  4. Values above zero for the NRI and IDI indicate improved risk prediction and discrimination with the addition of biomarkers to the model
  5. 2hPG: 2-h plasma glucose; BMI: body mass index; FGF21: fibroblast growth factor 21; FPG: fasting plasma glucose; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; IDI: integrated discrimination improvement; LDL-C: low-density lipoprotein cholesterol; NRI: net reclassification improvement; Ref.: referent; SBP: systolic blood pressure
  6. aLoge-transformed before analysis