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Table 6 Changes induced by weight loss according to hypertension

From: High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery

 

NT

p ^

HT

p ^

Δ Weight

− 22.0 ± 12.2

< 0.0001

− 20.9 ± 14.6

< 0.0001

Δ BMI

− 8.2 ± 4.3

< 0.0001

− 7.9 ± 5.0

< 0.0001

Δ Waist circumference

− 15.4 ± 10.0

< 0.0001

− 15.3 ± 10.3

< 0.0001

Δ FPG

− 11.5 ± 18.2

< 0.0001

− 24.1 ± 35.7

< 0.0001

Δ 1hPG

− 34.3 ± 45.3

< 0.0001

− 41.5 ± 55.6

< 0.0001

Δ 2hPG

− 28.1 ± 45.9

< 0.0001*

− 48.1 ± 65.8

< 0.0001*

Δ Insulin

− 8.8 ± 10.6

< 0.0001

− 8.2 ± 7.6

< 0.0001

Δ HOMA-IR

− 2.5 ± 3.1

< 0.0001

− 3.3 ± 3.5

< 0.0001

Δ HbA1c

− 0.5 ± 0.9

< 0.0001

− 0.9 ± 1.1

< 0.0001

Δ Total cholesterol

0.5 ± 29.5

0.8489*

4.0 ± 33.2

0.3935*

Δ HDL-cholesterol

6.2 ± 9.7

< 0.0001*

6.7 ± 10.1

< 0.0001*

Δ Triglycerides

− 38.8 ± 65.0

< 0.0001

− 46.4 ± 76.9

< 0.0001

Δ Systolic BP

− 2.8 ± 11.4

0.0156

− 9.0 ± 18.4

0.0003

Δ Diastolic BP

− 1.4 ± 9.7

0.0948

− 5.8 ± 12.2

0.0004

Δ Creatinine

0.0 ± 0.1

0.7750

0.0 ± 0.1

0.1481

Δ Leptin

− 19.1 ± 12.9

< 0.0001

− 15.5 ± 12.6

0.0002

Δ Ferritin

− 15.9 ± 41.8

0.0042

− 16.8 ± 125.5

0.8130

Δ Transferrin

0.0 ± 0.4

0.5693

0.1 ± 0.4

0.3586

Δ Iron

1.7 ± 28.8

0.5846

1.9 ± 28.9

0.6453

Δ Albumin

0.2 ± 4.2

0.6064

− 0.2 ± 3.7

0.6609

Δ Calcium

0.04 ± 0.12

0.0037*

0.02 ± 0.11

0.1442*

Δ Sodium

0.41 ± 0.30

0.2717*

1.4 ± 0.36

< 0.0001*

Δ Supine PRA

0.1 ± 3.0

0.3616

− 2.7 ± 6.0

0.0005

Δ Upright PRA

0.4 ± 6.0

0.8130

− 3.6 ± 10.0

0.0605

Δ Supine ALD

− 0.2 ± 4.8

0.0529

− 1.4 ± 3.2

0.0015

Δ Upright ALD

0.3 ± 10.0

0.2545

− 1.6 ± 5.5

0.0796

Δ Upright ALD/PRA

− 0.5 ± 8.2

0.7108

− 0.7 ± 9.6

0.5834

Δ Urinary free cortisol

− 13.4 ± 56.5

0.1085*

− 20.4 ± 56.7

0.0731*

Δ Uric-acid

− 0.4 ± 1.2

0.0009*

− 0.5 ± 1.0

0.0011*

Δ Hypoglycemic therapya

0.1 ± 1.2

0.7500

− 0.1 ± 1.2

1.0000

  1. – indicates decrease
  2. NT normotensive, HT hypertensive, BMI body mass index, FPG fasting plasma glucose, 1hPG 1-hour plasma glucose, 2hPG 2-hour plasma glucose, BP blood pressure, PRA plasma renin activity, ALD aldosterone
  3. ^Non-parametric Wilcoxon signed rank test for paired data
  4. *Paired T test
  5. aPills per day
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Cardiovascular Diabetology

ISSN: 1475-2840