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Table 1 Anthropometric and metabolic characteristics of the study subjects stratified according to TRB3 genotype

From: The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals

Variables

Whole study group

N = 2426

Q84Q

N = 1792

Q84R

N = 573

R84R

N = 61

P

Gender (M/F)

1182/1244

864/928

289/284

29/32

0.640

Age (years)

51 ± 14

51 ± 14

52 ± 15

52 ± 14

0.270*

BMI (Kg/m2)

29.73 ± 6.0

29.64 ± 6.04

29.52 ± 5.93

29.73 ± 7.37

0.909

Waist circumference (cm)

100.5 ± 14.2

100.6 ± 14.3

100.4 ± 14.1

98.5 ± 12.1

0.429

Smoking status (never/current/ex) (%)

1792/573/61

1021/367/404

407/115/144

40/10/11

0.451

SBP (mmHg)

133 ± 18

133 ± 19

133 ± 18

137 ± 20

0.204

DBP (mmHg)

81 ± 11

81 ± 11

81 ± 11

85 ± 11

0.058

Pulse pressure (mmHg)

51 ± 14

51 ± 14

52 ± 14

51 ± 14

0.891

Heart rate (beats min−1)

71 ± 10

70 ± 10

71 ± 11

70 ± 10

0.179

Rate pressure product (mmHg × beats min−1)

9443 ± 2014

9403 ± 2019

9532 ± 1978

9783 ± 2164

0.271

Tot-Col (mg/dl)

201 ± 40

202 ± 41

197 ± 39

204 ± 35

0.106

HDL-Col (mg/dl)

52 ± 14

52 ± 14

51 ± 14

53 ± 15

0.709

Triglycerides (mg/dl)

128 ± 78

129 ± 78

127 ± 79

123 ± 57

0.408

Fasting glucose (mg/dl)

93 ± 10

93 ± 10

93 ± 11

92 ± 8

0.720

Fasting insulin (µU/ml)

10.2 ± 4.1

9.9 ± 3.9

10.2 ± 4.1

11.8 ± 4.4

0.02

HOMA-IR

2.33 ± 0.96

2.28 ± 0.94

2.34 ± 0.97

2.68 ± 1.01

0.03

eGFR (ml/min/1.73 m2)

97 ± 22

97 ± 22

96 ± 22

95 ± 27

0.128

NGT/Prediabetes

1508/918

1110/682

353/220

45/16

0.165

ACE inhibitor therapy, No. (%)

497 (20.5%)

361 (20.1%)

119 (20.8%)

17 (27.9%)

0.366

Angiotensin receptor blocker therapy, No. (%)

376 (15.5%)

275 (15.3%)

93 (16.2%)

8 (13.1%)

0.818

Calcium channel blocker, No. (%)

342 (14.1%)

252 (14.1%)

74 (12.9.6%)

14 (22.9%)

0.09

Beta blockers, No. (%)

387 (16.0%)

297 (16.6%)

77 (13.4%)

13 (21.3%)

0.104

Diuretic, No. (%)

439 (18.1%)

321 (17.9%)

108 (18.8%)

10 (16.4%)

0.828

Lipid-lowering drugs, No. (%)

280 (11.5%)

206 (11.5%)

67 (11.7%)

7 (11.5%)

0.992

  1. Data are means ± SD. Triglyceride levels were log transformed for statistical analysis, but values in the Table represent back transformation to the original scale. Categorical variables were compared by χ2 test. Differences of continuous variables between groups were tested by a general linear model. P values refer to results after adjustment for sex and age
  2. ACE angiotensin converting enzyme; BMI body mass index; SBP systolic blood pressure; DBP = diastolic blood pressure; HDL high density lipoprotein; NGT normal glucose tolerance
  3. *P values refer to results after adjustment for sex
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Cardiovascular Diabetology

ISSN: 1475-2840