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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition

Fig. 5

Bone marrow and spleen myelopoiesis evident in mice with diabetes. A Quantified proportions of bone marrow progenitor cells. LSK cells (Lineage−, Sca-1+, cKit+; haematopoietic stem cells), common myeloid progenitors (CMPs) and granulocyte myeloid progenitors (GMPs). B Proportions of spleen monocytes in ND (n = 7) vs. DM (n = 19) mice. C Proposed mechanism by which systemic monocytosis occurs in diabetic mice administered STZ-HFD. See Additional file 1: Figure S4 and S5 for full gating strategies for flow cytometry analysis. Data displayed as mean ± SEM. *P < 0.05, **P < 0.01 (Student’s unpaired t-test)

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Cardiovascular Diabetology

ISSN: 1475-2840