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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes

Fig. 1

Circulating microparticles characterization in plasma from T2DM. Plasma-derived microparticles were isolated from 23 subjects with normal glucose tolerance (NGT), 28 diabetic patients with HbA1c ≤ 7.0% (GGC) and 31 diabetic patients with HbA1c > 7.0% (PGC). a–d Microparticles were labelled with specific antibodies: a for platelet-derived MPs (CD62P+) (ANOVA, p < 0.0001), b for tissue factor bearing (CD142+) (ANOVA, p = 0.009), c for endothelial-derived MPs (CD62E+) (ANOVA, p < 0.0001), and d for leukocyte-derived MPs (CD45+) (ANOVA, p = 0.64). Values are mean ± SEM. The p-values were evaluated by ANOVA followed by a post-hoc Bonferroni test. e, f Correlations between CD62P+ MPs and glycated hemoglobin, and between CD62P + MPs and IL-6 plasma levels, respectively. Statistical significance was determined with linear regression. Dotted lines indicated the 95% of interval confidence

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Cardiovascular Diabetology

ISSN: 1475-2840