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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle‐stimulated endothelial senescence and dysfunction: protective effect of gliflozins

Fig. 1

Ang II up-regulates in a time- and concentration-dependent manner the protein level of SGLT1 and SGLT2 in ECs as assessed by Western blot (a, b) and immunofluorescence staining (c). SGLT1 and SGLT2 protein staining appears in red and nuclei are stained with DAPI (blue). Exposure of ECs to SGLT2 siRNA (40 nM) for 6 h prevented the stimulatory effect of Ang II on SGLT2 (d). Results are shown as representative immunoblots and micrography of immunofluorescence staining (upper and left panels) and corresponding cumulative data (lower and right panels). Data are expressed as mean ± SEM of n = 3. *P < 0.05 vs. control and #P < 0.05 vs. Ang II

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Cardiovascular Diabetology

ISSN: 1475-2840