Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction

Table 3 Invasive pressure volume loop parameters

	Sham + control	Sham + empa	MI + vehicle	MI + empa
SBP (mmHg)	127 ± 4	146 ± 3	120 ± 4*	132 ± 5^†
dP/dt_max	7623 ± 326	7903 ± 183	6010 ± 248	6292 ± 249
dP/dt_min	− 7834 ± 417	− 8234 ± 224	− 4870 ± 251	− 5248 ± 261
PRSW (mmHg)	74 ± 3	80 ± 3	62 ± 5*	75 ± 6^†
EDP (mmHg)	11.1 ± 0.6	10.2 ± 0.6	16.0 ± 1*	14 ± 1^‡
Tau (msec)	12.0 ± 0.5	12.1 ± 0.3	17.1 ± 0.5*	16.5 ± 0.5
EDPVR (mmHg/s)	0.029 ± 0.002	0.026 ± 0.002	0.046 ± 0.004*	0.054 ± 0.005

Data are expressed as mean ± SEM. N = 23–24 in sham + control and sham + empa groups; N = 19-23 in MI + vehicle and MI + empa groups
SBP systolic blood pressure, EDP end-diastolic pressure, dP/dt_max maximum rate of pressure rise, dP/dt_min maximal rate of pressure decline, EDPVR end-diastolic pressure volume relationship
* p < 0.05 vs. sham control group
^†p < 0.05 vs. MI +vehicle group
^‡p = 0.056 c/w MI + vehicle

ISSN: 1475-2840