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Table 3 Cumulative rates of major adverse cardiac events

From: Relationship between insulin resistance, coronary plaque, and clinical outcomes in patients with acute coronary syndromes: an analysis from the PROSPECT study

  Insulin sensitive (n = 234) Likely insulin resistance (n = 109) Diabetic insulin resistance (n = 65) Diabetes mellitus (n = 99) p value
Overall
 Major adverse cardiac events*a 15.5 (33) 17.6 (18) 29.9 (19) 27.7 (24) 0.01
 Cardiac death 2.4 (5) 0 (0) 3.2 (2) 1.2 (1) 0.38
 Myocardial infarctionb 0.9 (2) 1.0 (1) 5.0 (3) 7.2 (6) 0.01
 Cardiac death, cardiac arrest, or myocardial infarction 2.9 (6) 1.0 (1) 8.1 (5) 8.3 (7) 0.03
 Rehospitalization due to unstable or increasing angina 14.1 (30) 16.6 (17) 25.3 (16) 22.9 (20) 0.09
 Revascularization (PCI or CABG)c 10.9 (23) 14.7 (15) 27.1 (17) 23.5 (20) 0.003
 Stent thrombosisd 2.0 (4) 0 (0) 4.7 (3) 4.6 (4) 0.11
Culprit lesion
 Major adverse cardiac events*a 8.0 (17) 13.8 (14) 20.4 (13) 17.3 (15) 0.02
 Cardiac death 0 (0) 0 (0) 1.6 (1) 0 (0) 0.09
 Myocardial infarctione 0.5 (1) 0 (0) 1.6 (1) 4.6 (4) 0.02
 Cardiac death, cardiac arrest, or myocardial infarction 0.5 (1) 0 (0) 3.1 (2) 4.6 (4) 0.02
 Rehospitalization due to unstable or increasing angina 8.0 (17) 13.8 (14) 19.1 (12) 13.8 (12) 0.07
 Revascularization (PCI or CABG)* 6.2 (13) 10.8 (11) 17.5 (11) 15.2 (13) 0.02
Stent thrombosisc,d 0.0 (0) 0.0 (0) 4.7 (3) 3.4 (3) 0.004
 Non-culprit lesion
 Major adverse cardiac eventsa 9.2 (19) 8.9 (9) 19.2 (12) 16.5 (14) 0.057
 Cardiac death 0 (0) 0 (0) 0 (0) 0 (0)
 Myocardial infarction 0.0 (0) 1.0 (1) 3.4 (2) 1.4 (1) 0.13
 Rehospitalization due to unstable or increasing angina 9.2 (19) 7.9 (8) 17.5 (11) 15.1 (13) 0.10
 Revascularization (PCI or CABG)f 7.8 (16) 7.9 (8) 19.2 (12) 14.1 (12) 0.03
Indeterminate events
 Major adverse cardiac eventsa 2.9 (6) 1.0 (1) 1.7 (1) 4.7 (4) 0.44
 Cardiac death 2.4 (5) 0 (0) 1.7 (1) 1.2 (1) 0.46
 Myocardial infarction 0.5 (1) 0 (0) 0 (0) 1.1 (1) 0.62
 Rehospitalization due to unstable or increasing angina 0.5 (1) 1.0 (1) 0 (0) 2.4 (2) 0.39
 Revascularization (PCI or CABG)f 0 (0) 0 (0) 0 (0) 0 (0)
  1. *p < 0.03 comparing insulin sensitive (IS) with diabetic insulin resistance (DIR) and diabetes mellitus (DM); a cardiac death or arrest, myocardial infarction, rehospitalization for unstable angina, or increasing angina; bp < 0.05 comparing IS and DM; cp < 0.005 comparing IS with DIR and DM; ddefinite or possible per Academic Research Consortium definition; ep = 0.01 comparing IS with DM; fp < 0.005 comparing IS with DIR. CABG, coronary artery bypass grafting; PCI, percutaneous coronary intervention