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Table 3 Association between glycemic abnormality and impaired LVGLS (> − 16.65%) stratified by BMI category

From: Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community

  BMI < 25 kg/m2 BMI ≥ 25 kg/m2
Abnormal HOMA-IR DM Abnormal HOMA-IR DM
Odds ratio
(95% CI)
p value Odds ratio
(95% CI)
p value Odds ratio
(95% CI)
p value Odds ratio
(95% CI)
p value
Univariable 7.66 (3.27–17.94)  < 0.001 5.78 (2.50–13.39)  < 0.001 1.80 (0.83–3.90) 0.134 4.96 (1.67–14.72) 0.004
Model 1 6.01 (2.52–14.33)  < 0.001 3.93 (1.63–9.48) 0.002 1.69 (0.77–3.71) 0.194 4.27 (1.40–13.01) 0.011
Model 2 4.66 (1.90–11.39)  < 0.001 3.00 (1.18–7.61) 0.021 1.43 (0.60–3.41) 0.415 3.40 (0.98–11.76) 0.054
Model 3 4.65 (1.89–11.44)  < 0.001 3.02 (1.16–7.82) 0.023 1.54 (0.64–3.73) 0.337 4.08 (1.14–14.57) 0.031
Model 4 4.59 (1.84–11.44) 0.001 2.93 (1.11–7.75) 0.030 1.62 (0.65–4.05) 0.300 5.02 (1.33–18.92) 0.017
  1. Reference; normal HOMA-IR
  2. Model 1: adjusted for age and sex
  3. Model 2: adjusted for Model 1 plus BMI, hypertension, hyperlipidemia and smoking status
  4. Model 3: adjusted for Model 2 plus echocardiographic parameters including LV mass index and E/e′
  5. Model 4: adjusted for Model 3 plus serum CRP and eGFR
  6. BMI  body mass index, CI confidence interval, CRP C-reactive protein, DM diabetes mellitus, E early diastolic transmitral flow velocity, e′ early diastolic mitral annular velocity, eGFR estimated glomerular filtration rate, GLS global longitudinal strain, HOMA-IR homeostatic model assessment of insulin resistance, LV left ventricle
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