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Table 3 Association between glycemic abnormality and impaired LVGLS (>ā€‰āˆ’ā€‰16.65%) stratified by BMI category

From: Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community

Ā 

BMIā€‰<ā€‰25Ā kg/m2

BMIā€‰ā‰„ā€‰25Ā kg/m2

Abnormal HOMA-IR

DM

Abnormal HOMA-IR

DM

Odds ratio

(95% CI)

p value

Odds ratio

(95% CI)

p value

Odds ratio

(95% CI)

p value

Odds ratio

(95% CI)

p value

Univariable

7.66 (3.27ā€“17.94)

ā€‰<ā€‰0.001

5.78 (2.50ā€“13.39)

ā€‰<ā€‰0.001

1.80 (0.83ā€“3.90)

0.134

4.96 (1.67ā€“14.72)

0.004

Model 1

6.01 (2.52ā€“14.33)

ā€‰<ā€‰0.001

3.93 (1.63ā€“9.48)

0.002

1.69 (0.77ā€“3.71)

0.194

4.27 (1.40ā€“13.01)

0.011

Model 2

4.66 (1.90ā€“11.39)

ā€‰<ā€‰0.001

3.00 (1.18ā€“7.61)

0.021

1.43 (0.60ā€“3.41)

0.415

3.40 (0.98ā€“11.76)

0.054

Model 3

4.65 (1.89ā€“11.44)

ā€‰<ā€‰0.001

3.02 (1.16ā€“7.82)

0.023

1.54 (0.64ā€“3.73)

0.337

4.08 (1.14ā€“14.57)

0.031

Model 4

4.59 (1.84ā€“11.44)

0.001

2.93 (1.11ā€“7.75)

0.030

1.62 (0.65ā€“4.05)

0.300

5.02 (1.33ā€“18.92)

0.017

  1. Reference; normal HOMA-IR
  2. Model 1: adjusted for age and sex
  3. Model 2: adjusted for Model 1 plus BMI, hypertension, hyperlipidemia and smoking status
  4. Model 3: adjusted for Model 2 plus echocardiographic parameters including LV mass index and E/eā€²
  5. Model 4: adjusted for Model 3 plus serum CRP and eGFR
  6. BMIā€‰ā€‰body mass index, CIā€‰confidence interval, CRP C-reactive protein, DMā€‰diabetes mellitus, E early diastolic transmitral flow velocity, eā€² early diastolic mitral annular velocity, eGFR estimated glomerular filtration rate, GLS global longitudinal strain, HOMA-IR homeostatic model assessment of insulin resistance, LV left ventricle