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Table 3 Estimated effects of dulaglutide on the first composite outcome

From: Total cardiovascular or fatal events in people with type 2 diabetes and cardiovascular risk factors treated with dulaglutide in the REWIND trail: a post hoc analysis

Composite event

Dulaglutide group

Placebo group

People spareda

Cox model

N (N/1000py)

N (N/1000py)

N (N/1000py)

HR (95% CI)

p

MACE or non-CV death

789 (31.2)

879 (35.3)

90 (4.1)

0.88 (0.80, 0.97)

0.011

MACE, UA, or non-CV death

859 (34.3)

933 (37.8)

74 (3.5)

0.91 (0.83, 0.99)

0.041

MACE, HF or non-CV death

880 (35.3)

983 (40.1)

103 (4.8)

0.88 (0.80, 0.96)

0.0054

MACE, Revasc, or non-CV death

1002 (40.8)

1090 (44.9)

88 (4.1)

0.91 (0.83, 0.99)

0.028

MACE, UA, HF, Revasc, or non-CV death

1097 (45.3)

1189 (49.8)

92 (4.5)

0.91 (0.84, 0.99)

0.024

  1. aDifference in numbers (and rate) of people experiencing a first composite event in the dulaglutide group versus the placebo group; CV, cardiovascular; py, person-year; MACE, major adverse cardiovascular events; UA, unstable angina; HF, heart failure; Revasc, revascularization