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Table 3 Adjusted hazard ratios associated with 10 mmHg lower blood pressure

From: Blood pressure and mortality in patients with type 2 diabetes and a recent coronary event in the ELIXA trial

 

Overall (n = 5852)

HR (95% CI) P

Per 10 mmHg ↓

Index ACS only (n = 3527)

HR (95% CI) P

Per 10 mmHg ↓

Additional CVD (n = 2325)

HR (95% CI) P

Per 10 mmHg ↓

P for interaction

Systolic blood pressure

1.05 (0.99–1.12) P = 0.10

0.95 (0.86–1.04) P = 0.26

1.13 (1.04–1.22) P = 0.002

0.005

Diastolic blood pressure

*

0.94 (0.79–1.12) P = 0.48

1.30 (1.13–1.49) P < 0.001

0.004

 For DBP < 80 mmHg

1.30 (1.11–1.51) P = 0.001

–

–

 

 For DBP ≥ 80 mmHg

0.91 (0.74–1.13) P = 0.39

–

–

 

Pulse pressure

1.02 (0.94–1.10) P = 0.65

0.95 (0.84–1.07) P = 0.36

1.07 (0.97–1.18) P = 0.19

0.12

  1. *Denotes significantly non-linear associations, where two separate hazard ratios (obtained by piece-wise Cox regression) are reported. Adjustments made for: randomization group, coronary revascularization history, age, sex, self-reported race, heart rate, BMI, smoking status, known duration of diabetes, glycated hemoglobin A1c, use of insulin, eGFR, the logarithm of the urinary albumin to creatinine ratio and the logarithm of the BNP level
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Cardiovascular Diabetology

ISSN: 1475-2840