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Table 2 Patient baseline characteristics according to their number of cardiometabolic conditions (diabetes, hypertension, dyslipidaemia)

From: Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)

  Number of cardiometabolic conditions  
None
n = 100
One
n = 96
Two or three n = 81 p
Age ≥ 70 years, n (%) 16 (16.0) 39 (40.6) 52 (64.2)  < 0.001
Male sex, n (%) 62 (62.0) 58 (60.4) 50 (61.7) 0.97
Body mass index (kg/m2) 25.4 [23.4–27.8]* 26.2 [24.6–28.7]** 27.2 [24.9–29.4]*** 0.12
Smoking ^ ^^ ^^^  
 Never, n (%) 73 (82.95) 66 (77.65) 53 (75.71) 0.57
 Ever, n (%) 15 (17.05) 19 (22.35) 17 (24.29)
   Ex, n (%) 11 (12.5) 14 (16.47) 15 (21.43) 0.50#
   Current, n (%) 4 (4.55) 5 (5.88) 2 (2.86)
Prior CV event, n (%) 3 (3.0) 8 (8.33) 19 (23.75)  < 0.001
Prior heart failure, n (%) 3 (3.0) 5 (5.21) 11 (14.86) 0.007
Prior malignancy, n (%) 4 (4.0) 5 (5.21) 7 (8.97) 0.35
Prior COPD, n (%) 7 (7.0) 12 (12.5) 20 (25.0) 0.002
Plasma glucose (mg/dL) 100 [90–114] 112 [96–136] 119 [100–159.5]  < 0.001
Serum creatinine (mg/dL) 0.8 [0.7–1] 0.88 [0.7–1.04] 1.02 [0.74–1.50] 0.010
ESR (mm/hr) 44.5 [36–55] 24 [22–54] 78 [41–93] 0.10
CRP (mg/L) 2.29 [0.72–4.83] 3.18 [0.99–9.64] 4.58 [1.68–9.43] 0.043
Lactate dehydrogenase (U/L) 268 [216–318] 273 [211–370] 287 [223–382] 0.39
Fibrinogen (mg/dL) 501.5 [404–800] 464 [361–707] 538 [417–738] 0.46
D-dimer (mg/L) 416 [0.89–761.5] 464 [13.2–1250] 446 [2.2–1410] 0.23
White blood cell count (× 109/L) 5.95 [4–8.48] 6.09 [5.09–8.84] 6.47 [4.64–8.21] 0.62
Lymphocyte count (× 109/L) 1.11 [0.73–1.69] 1.07 [0.68–1.66] 1.08 [0.78–1.58] 0.81
Neutrophil count (× 109/L) 3.97 [2.60–5.75] 4.44 [3.14–6.52] 4.33 [2.80.6.77] 0.34
Blood gas analysis     
 pH 7.46 [7.43–7.49] 7.46 [7.42–7.49] 7.45 [7.42–7.49] 0.70
 PaO2/FIO2 ratio 381 [319–462] 350 [269–419] 319 [240–398] 0.002
 pCO2, mmHg 34 [31–37] 35 [32–39] 35.2 [31–38] 0.90
 HCO3, mmol/l 24.2 [22.5–25.9] 24.7` [22.4–26.0] 24.0 [21.6–27.1] 0.33
 Venous lactate, mmol/l 1.1 [0.8–1.6] 1.4 [0.9–6] 1.6 [1.1–7]  < 0.001
  1. #p-value for differences in never, ex and current smokers
  2. CV, cardiovascular; COPD, chronic obstructive pulmonary disease; ESR, erythrocytes sedimentation rate; CRP, c-reactive protein; PaO2, arterial pO2; FIO2, fraction of inspired oxygen. Body mass index data available for *45, **54 and ***51 patients
  3. Smoking data available for ^88, ^^85 and ^^^70 patients