Fig. 1

The effect of metformin on resting blood pressure and drop in blood pressure from resting in a supine position to standing. Estimates are adjusted for baseline values of outcomes, changes during trial in vitamin B12, methylmalonic acid ang HbA1c and in addition pre-trial treatment of metformin. Effects are shown as mmHg and 95% CI. *p = 0.02. **p = 0.045 Only estimates for Model 3 are illustrated