| Myocardial Infarction | Stroke | ||||||
---|---|---|---|---|---|---|---|---|
Events (n) | Incidence ratea | Model 1 | Model 2 | Events (n) | Incidence ratea | Model 1 | Model 2 | |
MetS | ||||||||
0 (n = 1,651,616) | 3714 | 0.51 | 1(ref.) | 1(ref.) | 3670 | 0.50 | 1(ref.) | 1(ref.) |
1 (n = 382,605) | 1648 | 0.98 | 1.49 (1.41, 1.58) | 1.40 (1.32, 1.49) | 1688 | 1.01 | 1.44 (1.36, 1.52) | 1.36 (1.28, 1.44) |
2 (n = 224,351) | 1298 | 1.32 | 1.84 (1.73, 1.96) | 1.68 (1.57, 1.80) | 1384 | 1.41 | 1.78 (1.67, 1.90) | 1.64 (1.53, 1.75) |
3 (n = 168,404) | 1235 | 1.68 | 2.17 (2.04, 2.32) | 1.95 (1.81, 2.09) | 1281 | 1.74 | 1.99 (1.87, 2.12) | 1.78 (1.66, 1.91) |
4 (n = 217,875) | 2627 | 2.76 | 3.28 (3.12, 3.46) | 2.87 (2.70, 3.05) | 2501 | 2.63 | 2.68 (2.55, 2.83) | 2.30 (2.17, 2.45) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |
BP | ||||||||
0 (n = 929,973) | 1755 | 0.43 | 1(ref.) | 1(ref.) | 1507 | 0.37 | 1(ref.) | 1(ref.) |
1 (n = 517,955) | 1431 | 0.63 | 1.23 (1.15, 1.32) | 1.19 (1.11, 1.28) | 1207 | 0.53 | 1.17 (1.09, 1.27) | 1.10 (1.02, 1.19) |
2 (n = 375,277) | 1334 | 0.81 | 1.44 (1.34, 1.55) | 1.36 (1.27, 1.47) | 1347 | 0.82 | 1.58 (1.47, 1.71) | 1.41 (1.30, 1.52) |
3 (n = 301,057) | 1400 | 1.06 | 1.74 (1.62, 1.87) | 1.61 (1.49, 1.74) | 1546 | 1.17 | 2.00 (1.86, 2.15) | 1.70 (1.57, 1.83) |
4 (n = 520,589) | 4602 | 2.02 | 2.64 (2.49, 2.80) | 2.37 (2.21, 2.53) | 4917 | 2.16 | 2.66 (2.50, 2.82) | 2.16 (2.02, 2.32) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |
WC | ||||||||
0 (n = 1,890,155) | 6319 | 0.76 | 1(ref.) | 1(ref.) | 6337 | 0.76 | 1(ref.) | 1(ref.) |
1 (n = 270,543) | 1292 | 1.09 | 1.24 (1.17, 1.32) | 1.12 (1.05, 1.19) | 1318 | 1.11 | 1.20 (1.13, 1.27) | 1.10 (1.04, 1.17) |
2 (n = 157,263) | 839 | 1.22 | 1.32 (1.22, 1.41) | 1.14 (1.06, 1.23) | 846 | 1.23 | 1.24 (1.16, 1.34) | 1.11 (1.03, 1.19) |
3 (n = 135,252) | 782 | 1.32 | 1.39 (1.29, 1.50) | 1.17 (1.09, 1.26) | 793 | 1.34 | 1.32 (1.23, 1.42) | 1.14 (1.06, 1.23) |
4 (n = 191,638) | 1290 | 1.54 | 1.61 (1.52, 1.71) | 1.29 (1.21, 1.37) | 1230 | 1.47 | 1.45 (1.36, 1.54) | 1.19 (1.11, 1.26) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |
Fasting glucose | ||||||||
0 (n = 1,192,187) | 3214 | 0.61 | 1(ref.) | 1(ref.) | 3026 | 0.57 | 1(ref.) | 1(ref.) |
1 (n = 610,969) | 2210 | 0.82 | 1.10 (1.04, 1.16) | 1.03 (0.97, 1.09) | 2153 | 0.80 | 1.09 (1.03, 1.16) | 1.01 (0.96, 1.07) |
2 (n = 348,772) | 1571 | 1.03 | 1.20 (1.13, 1.28) | 1.07 (1.00, 1.14) | 1548 | 1.01 | 1.16 (1.09, 1.24) | 1.02 (0.95, 1.08) |
3 (n = 223,765) | 1194 | 1.22 | 1.27 (1.19, 1.36) | 1.06 (0.99, 1.14) | 1214 | 1.24 | 1.22 (1.14, 1.31) | 0.99 (0.93, 1.07) |
4 (n = 269,158) | 2333 | 1.99 | 1.73 (1.64, 1.83) | 1.28 (1.19, 1.37) | 2583 | 2.20 | 1.73 (1.64, 1.83) | 1.22 (1.14, 1.30) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |
Triglycerides | ||||||||
0 (n = 1,177,953) | 2624 | 0.50 | 1(ref.) | 1(ref.) | 2866 | 0.55 | 1(ref.) | 1(ref.) |
1 (n = 454,920) | 1579 | 0.79 | 1.32 (1.24, 1.41) | 1.32 (1.24, 1.41) | 1631 | 0.81 | 1.24 (1.17, 1.32) | 1.26 (1.18, 1.34) |
2 (n = 315,637) | 1441 | 1.04 | 1.60 (1.50, 1.70) | 1.60 (1.49, 1.71) | 1430 | 1.03 | 1.42 (1.34, 1.52) | 1.46 (1.36, 1.56) |
3 (n = 281,844) | 1434 | 1.16 | 1.70 (1.59, 1.81) | 1.71 (1.59, 1.84) | 1493 | 1.21 | 1.59 (1.49, 1.69) | 1.64 (1.53, 1.76) |
4 (n = 414,497) | 3444 | 1.90 | 2.61 (2.48, 2.75) | 2.61 (2.44, 2.79) | 3104 | 1.71 | 2.09 (1.99, 2.20) | 2.16 (2.02, 2.30) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |
HDL-C | ||||||||
0 (n = 1,679,086) | 4486 | 0.61 | 1(ref.) | 1(ref.) | 4740 | 0.64 | 1(ref.) | 1(ref.) |
1 (n = 380,468) | 1652 | 0.99 | 1.49 (1.41, 1.57) | 1.44 (1.36, 1.53) | 1615 | 0.97 | 1.33 (1.26, 1.41) | 1.33 (1.26, 1.41) |
2 (n = 212,105) | 1170 | 1.25 | 1.76 (1.65, 1.88) | 1.68 (1.57, 1.80) | 1117 | 1.20 | 1.50 (1.40, 1.60) | 1.49 (1.39, 1.59) |
3 (n = 154,983) | 992 | 1.46 | 1.97 (1.84, 2.11) | 1.86 (1.73, 2.00) | 989 | 1.45 | 1.73 (1.61, 1.85) | 1.71 (1.59, 1.84) |
4 (n = 218,209) | 2222 | 2.32 | 2.84 (2.70, 2.99) | 2.61 (2.47, 2.76) | 2063 | 2.15 | 2.28 (2.17, 2.41) | 2.18 (2.06, 2.30) |
P for trend |  |  | < 0.0001 | < 0.0001 |  |  | < 0.0001 | < 0.0001 |