Cardiovascular Diabetology

Table 2 Linear regression analysis assessing the effects of potential risk factors on plaque volume progression

From: Impact of long-term glucose variability on coronary atherosclerosis progression in patients with type 2 diabetes: a 2.3 year follow-up study

Variables^a	Univariate			Multivariate^b
Variables^a	Sβ	95%CI	P-value	Sβ	95%CI	P-value
Annual change in TPV
CV-HbA1C	0.242	0.062, 0.438	0.004	0.241	0.019, 0.462	0.034
HbA1C	0.250	0.154, 0.346	< 0.001	0.275	0.073, 0.477	0.009
CV-FPG	0.233	0.076, 0.420	0.003	0.265	0.060, 0.465	0.012
FPG	0.245	0.149, 0.341	< 0.001	0.270	0.041, 0.499	0.022
2h-PBG	0.299	0.204, 0.394	< 0.001	0.251	0.022, 0.760	0.051
LDL-C	0.236	0.140, 0.332	< 0.001	0.243	0.089, 0.562	0.023
HOMA-IR	0.194	0.036, 0.292	< 0.001	− 0.046	− 0.264, 0.172	0.671
Anti-platelet	− 0.156	− 0.254, − 0.058	0.002	− 0.281	− 0.525, − 0.037	0.025
Statin	− 0.130	− 0.228, − 0.032	0.010	− 0.278	− 0.508, − 0.049	0.019
Alcohol	− 0.116	− 0.214, − 0.012	0.021	− 0.193	− 0.386, 0.001	0.052
Annual TPV progression rate
CV-HbA1C	0.243	0.078, 0.439	0.006	0.214	0.023, 0.405	0.029
HbA1C	0.282	0.187, 0.377	< 0.001	0.362	0.132, 0.591	0.003
CV-FPG	0.265	0.069, 0.460	0.004	0.218	0.037, 0.399	0.019
FPG	0.257	0.161, 0.352	< 0.001	0.253	0.039, 0.467	0.022
2h-FBG	0.316	0.221, 0.410	< 0.001	0.215	0.024, 0.665	0.055
LDL-C	0.230	0.133, 0.326	< 0.001	0.295	0.106, 0.484	0.003
HOMA-IR	0.205	0.108, 0.303	< 0.001	− 0.122	− 0.324, 0.080	0.231
Anti-platelet	− 0.170	− 0.267, − 0.073	0.001	− 0.311	− 0.540, − 0.082	0.009
Statin	− 0.148	− 0.246, − 0.050	0.003	− 0.383	− 0.614, − 0.152	0.002
Alcohol	− 0.116	− 0.215, − 0.017	0.021	− 0.201	− 0.407, − 0.041	0.058

CV, coefficient of variation; FPG, fasting plasma glucose; PBG, postprandial blood glucose; HOMA-IR, homeostatic model assessment of insulin resistance; LDL-C, low density lipoprotein cholesterol
^aThe variables which got a level of P < 0.05 in the univariate analysis was presented in this table
^bMultivariate regression analysis was adjusted for age, sex, BMI, diabetes duration, smoking, alcohol consumption, hypertension, hypoglycemia rate, triglyceride, LDL-C, HDL-C, FPG, 2h-FBG, HbA1c, eGFR, UA, HOMA-IR, UACR, and medications

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