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Table 4 Associations between cardiac stress biomarkers and the combined incident prediabetes/type 2 diabetes endpoint

From: Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

Biomarkers

Ncases/non-cases

Model

OR [95% CI]

P

MR-proANP

266/1229

Model 1

0.91 [0.76; 1.09]

0.297

Model 2

0.94 [0.78; 1.14]

0.539

Copeptin

145/657

Model 1

1.30 [1.03; 1.64]

0.027

Model 2

1.29 [1.02; 1.63]

0.033

CT-proET-1

145/657

Model 1

1.15 [0.95; 1.40]

0.154

Model 2

1.15 [0.94; 1.41]

0.169

MR-proADM

145/657

Model 1

1.09 [0.85; 1.38]

0.497

Model 2

1.08 [0.84; 1.39]

0.543

  1. ORs [95% CI] were calculated per 1-SD increment of cardiac stress biomarkers
  2. Model 1: adjusted for age, sex, waist circumference and height
  3. Model 2: Model 1 + actual hypertension, ratio of total cholesterol and HDL, triglycerides, smoking status, physical activity and parental history of diabetes
  4. Italic values indicate significant P values (P < 0.05)
  5. CI, confidence interval; CT-proET-1, C-terminal pro-endothelin-1; MR-proADM, mid-regional pro-adrenomedullin; MR-proANP, mid-regional pro-atrial natriuretic peptide; OR, odds ratio; SD, standard deviation
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Cardiovascular Diabetology

ISSN: 1475-2840