Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

Table 3 Associations between cardiac stress biomarkers and incident type 2 diabetes

Biomarkers	N_{cases/non-cases}	Model	OR [95% CI]	P
MR-proANP	119/1645	Model 1	0.70 [0.55; 0.89]	0.004
MR-proANP	119/1645	Model 2	0.75 [0.58; 0.96]	0.025
Copeptin	72/888	Model 1	1.03 [0.78; 1.36]	0.824
Copeptin	72/888	Model 2	1.05 [0.79; 1.40]	0.730
CT-proET-1	72/888	Model 1	0.93 [0.69; 1.25]	0.626
CT-proET-1	72/888	Model 2	0.82 [0.59; 1.14]	0.234
MR-proADM	72/888	Model 1	0.87 [0.62; 1.20]	0.389
MR-proADM	72/888	Model 2	0.85 [0.59; 1.21]	0.358

ORs [95% CI] were calculated per 1-SD increment of cardiac stress biomarkers
Model 1: adjusted for age, sex, waist circumference and height
Model 2: Model 1 + actual hypertension, ratio of total cholesterol and HDL, triglycerides, smoking status, physical activity and parental history of diabetes
Italic values indicate significant P values (P < 0.05)
CI, confidence interval; CT-proET-1, C-terminal pro-endothelin-1; MR-proADM, mid-regional pro-adrenomedullin; MR-proANP, mid-regional pro-atrial natriuretic peptide; OR, odds ratio; SD, standard deviation

ISSN: 1475-2840