Table 2 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in endothelial cells (SIRT1)
From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
miRNA | Up/downregulation (obesity) | Refs. | Function | Refs. | Target | Refs. |
|---|---|---|---|---|---|---|
miR-204 | Up | [91] | EC dysfunction | [91] | SIRT1 | [91] |
miR-217 | Up | [101] | Premature cell senescence | [98] | SIRT1 | [98] |
miR-34a | Up | [100] | Premature cell senescence | [99] | SIRT1 | [100] |
miR-149 | Down | Regression of atherosclerotic lesions | [104] | SIRT1 | [103] | |
miR-132 | Up | Macrophage infiltration in ECs | SIRT1 | [106] |