Fig. 1

Multivariable-adjusted risk ratios for all-cause mortality in all participants (a), diabetic patients (b) and controls (c). The solid lines indicate multivariate-adjusted risk ratios, and the shaded area indicate the 95% CIs derived from restricted cubic spline regression. A knot is located at the 25, 50, and 75th percentiles for ANGPTL8, and the highest and lowest 0.5% of ANGPTL8 was trimmed. The logistic regression was adjusted for age, sex, and BMI