Table 1 Characteristics of patients with aortic stenosis with or without concomitant diabetes mellitus (DM)
Variable | NonDM patients (n = 76) | DM patients (n = 50) | p-value |
|---|---|---|---|
Age, years | 68 [66–72] | 70 [66–74] | 0.18 |
Male, n (%) | 41 (53.9) | 31 (62) | 0.37 |
BMI, kg/m2 | 28.4 [26.6–31.2] | 31.3 [28.7–34.5] | < 0.001 |
Risk factors, n (%) | |||
Arterial hypertension | 70 (92.1) | 50 (100) | 0.08 |
Hypercholesterolemia | 20 (26.3) | 10 (20) | 0.52 |
Current smoking | 9 (11.8) | 8 (16) | 0.60 |
Medications, n (%) | |||
Beta-blockers | 61 (80.3) | 47 (94) | 0.038 |
Acetylsalicylic acid | 52 (68.4) | 40 (80) | 0.22 |
ACE inhibitors | 53 (69.7) | 45 (90) | 0.008 |
Statins | 56 (73.7) | 46 (92) | 0.011 |
Insulin | 0 | 14 (28) | < 0.0001 |
Metformin | 0 | 36 (72) | < 0.0001 |
Echocardiographic parameters | |||
Mean gradient, mmHg | 48 [42–59] | 52 [43–66] | 0.067 |
Maximum gradient, mmHg | 82.3 ± 14.2 | 89.2 ± 12.3 | 0.054 |
LVEF, % | 60 [55–65] | 60 [58–64] | 0.39 |
AVA, cm2 | 0.86 [0.7–0.95] | 0.78 [0.6–0.8] | 0.048 |
Laboratory investigation | |||
Fibrinogen, g/L | 3.4 ± 0.8 | 3.6 ± 0.6 | 0.28 |
Creatinine, µmol/L | 74 [65–89] | 81 [74–100] | 0.011 |
hsCRP, mg/L | 1.2 [1.0–4.0] | 1.0 [1.0–2.0] | 0.34 |
Glucose, mmol/L | 5.2 [4.9–5.6] | 7.5 [5.9–9.1] | < 0.0001 |
HbA1c, % | 5.4 [5.2–5.7] | 6.8 [6.3–7.8] | < 0.0001 |
Insulin, µIU/mL | 16.5 [13.1–19.9] | 16.4 [12.3–23.4] | 0.41 |
Fructosamine, µmol/L | 225 [217–236] | 262 [241–291] | < 0.0001 |
TC, mmol/L | 4.1 [3.7–4.8] | 3.8 [3.0–4.6] | 0.06 |
LDL-C, mmol/L | 2.6 [2.1–3.3] | 2.3 [1.5–3.1] | 0.17 |
HDL-C, mmol/L | 1.3 [1.1–1.6] | 1.2 [1.0–1.4] | 0.039 |
Triglycerides, mmol/L | 1.2 [0.9–1.8] | 1.5 [1.2–2.0] | 0.27 |