Fig. 2

Mediating effects. Mediating effects are presented as indirect effects of T2DM on RV structure and function (absolute effect on left Y-axis, relative effect in percentages on right Y-axis) through potential mediators. All analyses are adjusted for age, office systolic blood pressure, antihypertensive medication, smoking status, prior cardiovascular disease, waist circumference albuminuria, eGFR, total to high density lipoprotein cholesterol ratio, triglycerides, the use of lipid-modifying medication. RV right ventricle, RA right atrium, LVMI left ventricular mass index, E/E′ peak flow velocity E/longitudinal velocities E ratio, LVEF left ventricular ejection fraction, TR max grad maximum gradient of the tricuspid valve