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Table 2 Joinpoint analysis of trends in age-standardized event rates of diabetes-related complications in women with diabetes

From: Trends in diabetes-related complications in Hong Kong, 2001–2016: a retrospective cohort study

Complications Event rates (per 10,000) Time period 1 Time period 2 Time period 3
2001 2016 AAPC (95% CI) Year APC (95% CI) Year APC (95% CI) Year APC (95% CI)
CHD
 All ages 225.8 50.8 − 9.9 (− 11.8, − 7.9)* 2001–2005 − 16.3 (− 20.0, − 12.4)* 2005–2010 − 3.2 (− 8.4, 2.4) 2010–2016 − 10.8 (− 13.6, − 7.9)*
 20–44 years 18.6 12.5 − 2.8 (− 7.6, 2.3) 2001–2016 − 2.8 (− 7.6, 2.3)     
 45–64 years 240.7 43.0 − 10.9 (− 12.1, − 9.8)* 2001–2005 − 19.6 (− 23.2, − 15.8)* 2005–2016 − 7.6 (− 8.6, − 6.6)*   
 65–74 years 623.5 94.0 − 11.9 (− 12.8, − 10.9)* 2001–2005 − 18.5 (− 20.4, − 16.5)* 2005–2011 − 6.0 (− 7.9, − 4.3)* 2011–2016 − 13.0 (− 14.8, − 11.2)*
 ≥ 75 years 727.3 223.2 − 7.7 (− 8.7, − 6.6)* 2001–2005 − 10.1 (− 13.0, − 7.1)* 2005–2010 − 0.83 (− 3.2, 1.6) 2010–2016 − 11.4 (− 12.5, − 10.3)*
Stroke
 All ages 251.3 64.2 − 9.0 (− 9.6, − 8.4)* 2001–2004 − 16.9 (− 19.0, − 14.8)* 2004–2012 − 8.5 (− 9.1, − 7.9)* 2012–2016 − 3.7 (− 5.4, − 2.0)*
 20–44 years 41.5 28.2 − 4.4 (− 7.5, − 1.1)* 2001–2016 − 4.4 (− 7.5, − 1.1)*     
 45–64 years 216.1 52.3 − 9.2 (− 10.5, − 8.0)* 2001–2006 − 16.2 (− 19.3, − 12.9)* 2006–2016 − 5.5 (− 6.8, − 4.2)*   
 65–74 years 590.2 100.3 − 11.5 (− 13.0, − 10.0)* 2001–2004 − 19.2 (− 25.7, − 12.2)* 2004–2016 − 9.5 (− 10.5, − 8.5)*   
 ≥ 75 years 1044.8 249.7 − 9.4 (− 10.7, − 8.0)* 2001–2005 − 13.5 (− 18.3, − 8.4)* 2005–2016 − 7.8 (− 8.7, − 6.9)*   
Heart failure
 All ages 187.0 63.9 − 7.0 (− 8.0, − 6.0)* 2001–2005 − 13.0 (− 16.1, − 9.8)* 2005–2016 − 4.7 (− 5.7, − 3.8)*   
 20–44 years 9.2 13.9 3.4 (− 2.4, 9.4) 2001–2016 3.4 (− 2.4, 9.4)     
 45–64 years 87.4 25.6 − 8.2 (− 10.0, − 6.2)* 2001–2006 − 15.3 (− 20.0, − 10.3)* 2006–2016 − 4.4 (− 6.3, − 2.5)*   
 65–74 years 371.0 79.1 − 9.8 (− 11.2, − 8.4)* 2001–2005 − 15.7 (− 20.3, − 10.9)* 2005–2016 − 7.6 (− 8.8, − 6.4)*   
 ≥ 75 years 1273.3 454.3 − 5.9 (− 6.8, − 5.1)* 2001–2016 − 5.9 (− 6.8, − 5.1)*     
Hyperglycaemic crisis
 All ages 111.3 20.4 − 8.5 (− 10.5, − 6.5)* 2001–2016 − 8.5 (− 10.5, − 6.5)*     
 20–44 years 225.1 36.0 − 8.7 (− 10.8, − 6.6)* 2001–2016 − 8.7 (− 10.8, − 6.6)*     
 45–64 years 22.6 10.0 − 5.9 (− 9.1, − 2.6)* 2001–2008 − 12.4 (− 17.8, − 6.7)* 2008–2016 0.22 (− 4.5, 5.1)   
 65–74 years 8.5 4.0 − 7.5 (− 10.5, − 4.4)* 2001–2016 − 7.5 (− 10.5, − 4.4)*     
 ≥ 75 years 48.7 6.2 − 11.2 (− 15.2, − 6.9)* 2001–2006 − 28.2 (− 36.8, − 18.4)* 2006–2016 − 1.3 (− 5.7, 3.4)   
LEA
 All ages 21.6 5.9 − 9.1 (− 12.2, − 5.8)* 2001–2007 − 16.2 (− 22.1, − 9.9)* 2007–2016 − 4.0 (− 8.1, 0.32)   
 20–44 years 9.4 4.9 Not available 2001− 2006 − 15.5 (− 32.5, 5.9) 2008–2016 − 0.37 (− 16.5, 18.9)   
 45–64 years 11.9 5.2 − 6.4 (− 10.0, − 2.7)* 2001–2006 − 15.0 (− 23.7, − 5.2)* 2006–2016 − 1.8 (− 5.5, 2.0)   
 65–74 years 39.2 5.1 − 11.8 (− 14.2, − 9.4)* 2001–2016 − 11.8 (− 14.2, − 9.4)*     
 ≥ 75 years 102.2 14.4 − 11.5 (− 12.7, − 10.2)* 2001–2016 − 11.5 (− 12.7, − 10.2)*     
  1. CHD coronary heart disease, LEA lower-extremity amputation, AAPC average annual percent change, APC annual percent change
  2. P < 0.05. As no women aged 20–44 years had amputation event in 2007, trend analysis was performed for 2001–2006 and 2008–2016, separately