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Table 2 Joinpoint analysis of trends in age-standardized event rates of diabetes-related complications in women with diabetes

From: Trends in diabetes-related complications in Hong Kong, 2001–2016: a retrospective cohort study

Complications

Event rates (per 10,000)

Time period 1

Time period 2

Time period 3

2001

2016

AAPC (95% CI)

Year

APC (95% CI)

Year

APC (95% CI)

Year

APC (95% CI)

CHD

 All ages

225.8

50.8

− 9.9 (− 11.8, − 7.9)*

2001–2005

− 16.3 (− 20.0, − 12.4)*

2005–2010

− 3.2 (− 8.4, 2.4)

2010–2016

− 10.8 (− 13.6, − 7.9)*

 20–44 years

18.6

12.5

− 2.8 (− 7.6, 2.3)

2001–2016

− 2.8 (− 7.6, 2.3)

    

 45–64 years

240.7

43.0

− 10.9 (− 12.1, − 9.8)*

2001–2005

− 19.6 (− 23.2, − 15.8)*

2005–2016

− 7.6 (− 8.6, − 6.6)*

  

 65–74 years

623.5

94.0

− 11.9 (− 12.8, − 10.9)*

2001–2005

− 18.5 (− 20.4, − 16.5)*

2005–2011

− 6.0 (− 7.9, − 4.3)*

2011–2016

− 13.0 (− 14.8, − 11.2)*

 ≥ 75 years

727.3

223.2

− 7.7 (− 8.7, − 6.6)*

2001–2005

− 10.1 (− 13.0, − 7.1)*

2005–2010

− 0.83 (− 3.2, 1.6)

2010–2016

− 11.4 (− 12.5, − 10.3)*

Stroke

 All ages

251.3

64.2

− 9.0 (− 9.6, − 8.4)*

2001–2004

− 16.9 (− 19.0, − 14.8)*

2004–2012

− 8.5 (− 9.1, − 7.9)*

2012–2016

− 3.7 (− 5.4, − 2.0)*

 20–44 years

41.5

28.2

− 4.4 (− 7.5, − 1.1)*

2001–2016

− 4.4 (− 7.5, − 1.1)*

    

 45–64 years

216.1

52.3

− 9.2 (− 10.5, − 8.0)*

2001–2006

− 16.2 (− 19.3, − 12.9)*

2006–2016

− 5.5 (− 6.8, − 4.2)*

  

 65–74 years

590.2

100.3

− 11.5 (− 13.0, − 10.0)*

2001–2004

− 19.2 (− 25.7, − 12.2)*

2004–2016

− 9.5 (− 10.5, − 8.5)*

  

 ≥ 75 years

1044.8

249.7

− 9.4 (− 10.7, − 8.0)*

2001–2005

− 13.5 (− 18.3, − 8.4)*

2005–2016

− 7.8 (− 8.7, − 6.9)*

  

Heart failure

 All ages

187.0

63.9

− 7.0 (− 8.0, − 6.0)*

2001–2005

− 13.0 (− 16.1, − 9.8)*

2005–2016

− 4.7 (− 5.7, − 3.8)*

  

 20–44 years

9.2

13.9

3.4 (− 2.4, 9.4)

2001–2016

3.4 (− 2.4, 9.4)

    

 45–64 years

87.4

25.6

− 8.2 (− 10.0, − 6.2)*

2001–2006

− 15.3 (− 20.0, − 10.3)*

2006–2016

− 4.4 (− 6.3, − 2.5)*

  

 65–74 years

371.0

79.1

− 9.8 (− 11.2, − 8.4)*

2001–2005

− 15.7 (− 20.3, − 10.9)*

2005–2016

− 7.6 (− 8.8, − 6.4)*

  

 ≥ 75 years

1273.3

454.3

− 5.9 (− 6.8, − 5.1)*

2001–2016

− 5.9 (− 6.8, − 5.1)*

    

Hyperglycaemic crisis

 All ages

111.3

20.4

− 8.5 (− 10.5, − 6.5)*

2001–2016

− 8.5 (− 10.5, − 6.5)*

    

 20–44 years

225.1

36.0

− 8.7 (− 10.8, − 6.6)*

2001–2016

− 8.7 (− 10.8, − 6.6)*

    

 45–64 years

22.6

10.0

− 5.9 (− 9.1, − 2.6)*

2001–2008

− 12.4 (− 17.8, − 6.7)*

2008–2016

0.22 (− 4.5, 5.1)

  

 65–74 years

8.5

4.0

− 7.5 (− 10.5, − 4.4)*

2001–2016

− 7.5 (− 10.5, − 4.4)*

    

 ≥ 75 years

48.7

6.2

− 11.2 (− 15.2, − 6.9)*

2001–2006

− 28.2 (− 36.8, − 18.4)*

2006–2016

− 1.3 (− 5.7, 3.4)

  

LEA

 All ages

21.6

5.9

− 9.1 (− 12.2, − 5.8)*

2001–2007

− 16.2 (− 22.1, − 9.9)*

2007–2016

− 4.0 (− 8.1, 0.32)

  

 20–44 years

9.4

4.9

Not available

2001− 2006

− 15.5 (− 32.5, 5.9)

2008–2016

− 0.37 (− 16.5, 18.9)

  

 45–64 years

11.9

5.2

− 6.4 (− 10.0, − 2.7)*

2001–2006

− 15.0 (− 23.7, − 5.2)*

2006–2016

− 1.8 (− 5.5, 2.0)

  

 65–74 years

39.2

5.1

− 11.8 (− 14.2, − 9.4)*

2001–2016

− 11.8 (− 14.2, − 9.4)*

    

 ≥ 75 years

102.2

14.4

− 11.5 (− 12.7, − 10.2)*

2001–2016

− 11.5 (− 12.7, − 10.2)*

    
  1. CHD coronary heart disease, LEA lower-extremity amputation, AAPC average annual percent change, APC annual percent change
  2. P < 0.05. As no women aged 20–44 years had amputation event in 2007, trend analysis was performed for 2001–2006 and 2008–2016, separately