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Table 1 Joinpoint analysis of trends in age-standardized event rates of diabetes-related complications in men with diabetes

From: Trends in diabetes-related complications in Hong Kong, 2001–2016: a retrospective cohort study

Complications Event rates (per 10,000) Time period 1 Time period 2 Time period 3
2001 2016 AAPC (95% CI) Year APC (95% CI) Year APC (95% CI) Year APC (95% CI)
CHD
 All ages 477.3 146.0 − 7.6 (− 10.2, − 5.0)* 2001–2003 − 23.1 (− 38.8, − 3.3)* 2003–2016 − 5.0 (− 6.0, − 4.0)*   
 20–44 years 155.9 55.1 − 7.3 (− 15.0, 1.1) 2001–2003 − 32.2 (− 66.1, 35.7) 2003–2016 − 2.7 (− 6.0, 0.68)   
 45–64 years 651.9 199.8 − 7.6 (− 9.5, − 5.7)* 2001–2003 − 22.6 (− 32.2, − 11.7)* 2003–2007 − 7.5 (− 12.9, − 1.9)* 2007–2016 − 3.9 (− 4.9, − 3.0)*
 65–74 years 914.3 217.1 − 9.0 (− 11.1, − 6.8)* 2001–2006 − 13.7 (− 15.8, − 11.5)* 2006–2010 − 3.1 (− 8.4, 2.6) 2010–2016 − 8.9 (− 10.5, − 7.3)*
 ≥ 75 years 813.3 281.1 − 6.5 (− 8.7, − 4.2)* 2001–2006 − 9.3 (− 13.7, − 4.6)* 2006–2010 3.6 (− 4.5, 12.4) 2010–2016 − 10.4 (− 12.5, − 8.3)*
Stroke
 All ages 339.5 100.9 − 8.7 (− 9.8, − 7.5)* 2001–2005 − 15.3 (− 19.0, − 11.3)* 2005–2016 − 6.2 (− 7.1, − 5.2)*   
 20–44 years 56.2 50.3 − 1.8 (–4.6, 1.1) 2001–2016 − 1.8 (− 4.6, 1.1)     
 45–64 years 338.2 99.7 − 8.3 (− 9.6, − 7.1)* 2001–2005 − 16.3 (− 20.4, − 12.0)* 2005–2016 − 5.3 (− 6.1, − 4.4)*   
 65–74 years 788.5 157.5 − 10.5 (− 11.5, − 9.5)* 2001–2005 − 15.4 (− 18.8, − 12.0)* 2005–2016 − 8.7 (− 9.5, − 7.9)*   
 ≥ 75 years 1224.8 289.0 − 9.6 (− 10.6, − 8.6)* 2001–2005 − 14.8 (− 18.3, − 11.1)* 2005–2016 − 7.6 (− 8.3, − 7.0)*   
Heart failure
 All ages 228.6 83.1 − 6.4 (− 8.0, − 4.7)* 2001–2005 − 12.8 (− 18.3, − 7.0)* 2005–2016 − 3.9 (− 5.2, − 2.7)*   
 20–44 years 41.6 30.8 1.2 (− 2.4, 4.8) 2001–2016 1.2 (− 2.4, 4.8)     
 45–64 years 147.5 56.6 − 5.8 (− 8.1, − 3.5)* 2001–2006 − 13.7 (− 19.7, − 7.3)* 2006–2016 − 1.6 (− 3.7, 0.52)   
 65–74 years 431.9 116.4 − 8.5 (− 10.0, − 7.1)* 2001–2009 − 11.3 (− 13.3, − 9.2)* 2009–2016 − 5.3 (− 7.9, − 2.7)*   
 ≥ 75 years 1259.2 413.4 − 6.9 (− 8.7, − 5.1)* 2001–2005 − 13.0 (− 19.3, − 6.2)*     
Hyperglycaemic crisis
 All ages 81.5 33.3 − 6.6 (− 12.4, − 0.44)* 2001–2003 − 30.0 (− 57.9, 16.6) 2003–2016 − 2.4 (− 4.9, 0.24)   
 20–44 years 151.7 66.0 − 3.9 (− 6.2, − 1.5)* 2001–2016 − 3.9 (− 6.2, − 1.5)*     
 45–64 years 25.4 10.1 − 7.0 (− 10.6, − 3.2)* 2001–2005 − 22.3 (− 33.0, − 9.9)* 2005–2016 − 0.7 (− 3.5, 2.2)   
 65–74 years 23.2 4.0 − 12.2 (− 16.3, − 7.9)* 2001–2003 − 42.7 (− 60.4, − 17.2)* 2003–2016 − 6.2 (− 8.4, − 4.0)*   
 ≥ 75 years 42.3 5.5 − 13.2 (− 17.8, − 8.5)* 2001–2004 − 31.4 (− 48.0, − 9.5)* 2004–2016 − 8.0 (− 10.7, − 5.3)*   
LEA
 All ages 36.0 11.7 − 5.8 (− 7.2, − 4.4)* 2001–2016 − 5.8 (− 7.2, − 4.4)*     
 20–44 years 14.1 3.8 − 7.4 (− 19.5, 6.5) 2001–2006 − 8.7 (− 22.4, 7.5) 2006–2010 14.5 (− 17.5, 59.0) 2010–2016 − 18.9 (− 27.5, − 9.3)*
 45–64 years 37.5 18.4 − 2.8 (− 4.7, − 0.91)* 2001–2016 − 2.8 (− 4.7, − 0.91)*     
 65–74 years 48.0 16.4 − 8.0 (− 9.5, − 6.5)* 2001–2016 − 8.0 (− 9.5, − 6.5)*     
 ≥ 75 years 123.0 16.6 − 10.5 (− 12.1, − 8.9)* 2001–2016 − 10.5 (− 12.1, − 8.9)*     
  1. CHD coronary heart disease, LEA lower-extremity amputation, AAPC average annual percent change, APC annual percent change
  2. P < 0.05