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Table 4 Simple and multiple linear regression analyses between possible predictors and white matter hyperintensity volume

From: High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study

 Univariate analysisMultivariable analysis
 β (95% CI)P-valueβ (95% CI)P-value
Age, years0.056 (0.051 to 0.060)< 0.0010.054 (0.050 to 0.059)< 0.001
Sex, male0.025 (− 0.057 to 0.107)0.555− 0.012 (− 0.089 to 0.065)0.756
Body mass index, kg/m2− 0.001 (− 0.014 to 0.013)0.935− 0.008 (− 0.021 to 0.005)0.217
Use of antihypertensives0.384 (0.278 to 0.489)< 0.0010.168 (0.069 to 0.267)0.001
Use of antiplatelet agents0.305 (0.155 to 0.455)< 0.001− 0.019 (− 0.158 to 0.120)0.785
Systolic blood pressure, mmHg0.010 (0.008 to 0.013)< 0.001
Diastolic blood pressure, mmHg0.008 (0.005 to 0.012)< 0.001
Hemoglobin A1c, %*1.022 (0.614 to 1.431)< 0.001
Fasting glucose, mg/dL*0.648 (0.409 to 0.886)< 0.001
Insulin, µU/mL*0.086 (0.017 to 0.154)0.014
HOMA-IR*0.104 (0.041 to 0.166)0.001
Total cholesterol, mg/dL− 0.001 (− 0.002 to 0.000)0.206
LDL cholesterol, mg/dL− 0.002 (− 0.003 to 0.000)0.026
HDL cholesterol, mg/dL0.000 (− 0.003 to 0.003)0.980
Triglyceride, mg/dL*0.088 (0.005 to 0.171)0.037
White blood cell counts, × 103/μL0.051 (0.026 to 0.075)< 0.0010.040 (0.017 to 0.064)0.001
hs-CRP, mg/dL*0.012 (− 0.015 to 0.040)0.378
TyG index0.126 (0.054 to 0.198)0.0010.084 (0.013 to 0.154)0.020
  1. HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; TyG index: triglyceride-glucose index
  2. *These variables were transformed into a log scale
  3. This variable was transformed into a square root scale
  4. Adjusted with P < 0.05 in univariate analysis (age, use of antihypertensives, use of antiplatelet agents, White blood cell counts, and TyG index) and sex and BMI