Table 4 Simple and multiple linear regression analyses between possible predictors and white matter hyperintensity volume^†

Age, years

0.056 (0.051 to 0.060)

0.054 (0.050 to 0.059)

Sex, male

0.025 (− 0.057 to 0.107)

− 0.012 (− 0.089 to 0.065)

Body mass index, kg/m²

− 0.001 (− 0.014 to 0.013)

− 0.008 (− 0.021 to 0.005)

Use of antihypertensives

0.384 (0.278 to 0.489)

0.168 (0.069 to 0.267)

Use of antiplatelet agents

0.305 (0.155 to 0.455)

− 0.019 (− 0.158 to 0.120)

Systolic blood pressure, mmHg

0.010 (0.008 to 0.013)

–

–

Diastolic blood pressure, mmHg

0.008 (0.005 to 0.012)

–

–

Hemoglobin A1c, %^*

1.022 (0.614 to 1.431)

–

–

Fasting glucose, mg/dL^*

0.648 (0.409 to 0.886)

–

–

Insulin, µU/mL^*

0.086 (0.017 to 0.154)

–

–

HOMA-IR^*

0.104 (0.041 to 0.166)

–

–

Total cholesterol, mg/dL

− 0.001 (− 0.002 to 0.000)

–

–

LDL cholesterol, mg/dL

− 0.002 (− 0.003 to 0.000)

–

–

HDL cholesterol, mg/dL

0.000 (− 0.003 to 0.003)

–

–

Triglyceride, mg/dL^*

0.088 (0.005 to 0.171)

–

–

White blood cell counts, × 10³/μL

0.051 (0.026 to 0.075)

0.040 (0.017 to 0.064)

hs-CRP, mg/dL^*

0.012 (− 0.015 to 0.040)

–

–

TyG index

0.126 (0.054 to 0.198)

0.084 (0.013 to 0.154)