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Table 4 Simple and multiple linear regression analyses between possible predictors and white matter hyperintensity volume

From: High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study

 

Univariate analysis

Multivariable analysis

 

β (95% CI)

P-value

β (95% CI)

P-value

Age, years

0.056 (0.051 to 0.060)

< 0.001

0.054 (0.050 to 0.059)

< 0.001

Sex, male

0.025 (− 0.057 to 0.107)

0.555

− 0.012 (− 0.089 to 0.065)

0.756

Body mass index, kg/m2

− 0.001 (− 0.014 to 0.013)

0.935

− 0.008 (− 0.021 to 0.005)

0.217

Use of antihypertensives

0.384 (0.278 to 0.489)

< 0.001

0.168 (0.069 to 0.267)

0.001

Use of antiplatelet agents

0.305 (0.155 to 0.455)

< 0.001

− 0.019 (− 0.158 to 0.120)

0.785

Systolic blood pressure, mmHg

0.010 (0.008 to 0.013)

< 0.001

Diastolic blood pressure, mmHg

0.008 (0.005 to 0.012)

< 0.001

Hemoglobin A1c, %*

1.022 (0.614 to 1.431)

< 0.001

Fasting glucose, mg/dL*

0.648 (0.409 to 0.886)

< 0.001

Insulin, µU/mL*

0.086 (0.017 to 0.154)

0.014

HOMA-IR*

0.104 (0.041 to 0.166)

0.001

Total cholesterol, mg/dL

− 0.001 (− 0.002 to 0.000)

0.206

LDL cholesterol, mg/dL

− 0.002 (− 0.003 to 0.000)

0.026

HDL cholesterol, mg/dL

0.000 (− 0.003 to 0.003)

0.980

Triglyceride, mg/dL*

0.088 (0.005 to 0.171)

0.037

White blood cell counts, × 103/μL

0.051 (0.026 to 0.075)

< 0.001

0.040 (0.017 to 0.064)

0.001

hs-CRP, mg/dL*

0.012 (− 0.015 to 0.040)

0.378

TyG index

0.126 (0.054 to 0.198)

0.001

0.084 (0.013 to 0.154)

0.020

  1. HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; TyG index: triglyceride-glucose index
  2. *These variables were transformed into a log scale
  3. This variable was transformed into a square root scale
  4. Adjusted with P < 0.05 in univariate analysis (age, use of antihypertensives, use of antiplatelet agents, White blood cell counts, and TyG index) and sex and BMI