Fig. 3

Loess spline curves of long-term LVEF trajectories in diabetic patients based on clinical modifiers. a Aetiology: ischemic (blue) vs. non-ischemic (yellow) aetiology. P for trajectory changes on LVEF < 0.001 for both groups. P for comparison between groups < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. b HF Duration: ≤ 12 months (blue) vs. > 12 months (yellow). P value for trajectory changes on LVEF < 0.001 for both groups. P for comparison between groups < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. c Sex: women (blue) vs. men (yellow). P for trajectory changes on LVEF < 0.001 for both sexes. P for comparison between sexes < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. d Optimal (blue) vs. non-optimal glycemic (yellow) control. P for trajectory changes on LVEF < 0.001. P for comparison between glycemic control groups 0.35. Shaded regions displayed around curves represent the confidence interval at level = 0.95