Cardiovascular Diabetology

Table 6 Associations of continuous and dichotomous mtDNA 8-OHdG with 1-year outcomes after coronary revascularization

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

Outcomes	Continuous mtDNA 8-OHdG		Dichotomous mtDNA 8-OHdG
	HR (95%CI)^a	P^a	No. of events^b		HR (95%CI)^a	P^a
	HR (95%CI)^a	P^a	High (n = 344)	Low (n = 357)	HR (95%CI)^a	P^a
MACCE	1.59 (1.33–1.90)	< 0.001	78 (22.7)	31 (8.7)	2.74 (1.80–4.17)	< 0.001
All-cause death	2.06 (1.59–2.66)	< 0.001	34 (9.9)	11 (3.1)	3.36 (1.69–6.69)	< 0.001
Cardiac death	1.92 (1.33–2.78)	< 0.001	19 (5.5)	5 (1.4)	3.80 (1.40–10.3)	0.009
Repeat revascularization	1.26 (0.98–1.62)	0.078	47 (13.7)	19 (5.3)	2.67 (1.55–4.57)	< 0.001
Non-fatal MI	1.42 (0.91–2.22)	0.126	12 (3.5)	7 (2.0)	2.30 (0.89–5.92)	0.085
Non-fatal stroke	1.45 (0.59–3.58)	0.417	3 (0.9)	2 (0.6)	1.71 (0.27–10.8)	0.569

MACCE major adverse cardiovascular and cerebral events, MI myocardial infarction
^aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
^bThe cutoff that categorized the value of mtDNA 8-OHdG as high or low was 3.22 ∆ct based on the results of time-dependent ROC

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com