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Table 6 Associations of continuous and dichotomous mtDNA 8-OHdG with 1-year outcomes after coronary revascularization

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

OutcomesContinuous mtDNA 8-OHdGDichotomous mtDNA 8-OHdG
HR (95%CI)aPaNo. of eventsbHR (95%CI)aPa
High (n = 344)Low (n = 357)
MACCE1.59 (1.33–1.90)< 0.00178 (22.7)31 (8.7)2.74 (1.80–4.17)< 0.001
All-cause death2.06 (1.59–2.66)< 0.00134 (9.9)11 (3.1)3.36 (1.69–6.69)< 0.001
Cardiac death1.92 (1.33–2.78)< 0.00119 (5.5)5 (1.4)3.80 (1.40–10.3)0.009
Repeat revascularization1.26 (0.98–1.62)0.07847 (13.7)19 (5.3)2.67 (1.55–4.57)< 0.001
Non-fatal MI1.42 (0.91–2.22)0.12612 (3.5)7 (2.0)2.30 (0.89–5.92)0.085
Non-fatal stroke1.45 (0.59–3.58)0.4173 (0.9)2 (0.6)1.71 (0.27–10.8)0.569
  1. MACCE major adverse cardiovascular and cerebral events, MI myocardial infarction
  2. aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
  3. bThe cutoff that categorized the value of mtDNA 8-OHdG as high or low was 3.22 ∆ct based on the results of time-dependent ROC