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Table 3 Associations between metformin use at hospital admission for AMI and MACE over median follow-up of 343 (IQR 1–1436) days using propensity score analysis

From: Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

Endpoint

Hazard ratio (95% CI)

P value

Primary endpoint

 MACE (composite of cardiovascular mortality, AMI and stroke)

1.13 (1.03–1.23)

0.006

Components of primary endpoint

 Cardiovascular mortality

1.12 (1.00–1.25)

0.044

 AMI

1.07 (0.95–1.21)

0.273

 Stroke

1.00 (0.83–1.21)

0.977

Secondary endpoints

 All-cause mortality

1.02 (0.94–1.11)

0.660

 HF hospitalisation

1.18 (1.06–1.31)

0.002

  1. Adjusted for: age at index AMI, sex, ethnicity, BMI, fasted glucose, HbA1c, smoking status, total serum cholesterol, previous HF, previous stroke, previous TIA, previous AAA, previous angina and if ever prescribed insulin prior to index AMI
  2. AMI acute myocardial infarction, HF heart failure