| | Model | HbA1c groups | Each percent of HbA1c | p trend |
|---|
| ≤ 5.6% | 5.7–6.4% | ≥ 6.5% |
|---|
| Sensitivity-1 | n | 12,562 | 4083 | 218 | – | – |
| CAP case | 1947 | 1951 | 44 | – | – |
| Multivariate adjusted | Ref | 3.01 (2.81, 3.23) | 1.42 (1.04, 1.95) | 2.94 (2.67, 3.22) | < 0.001 |
| Sensitivity-2 | n | 12,636 | 2959 | 119 | – | – |
| CAP case | 2649 | 921 | 50 | – | – |
| Multivariate adjusted | Ref | 1.25 (1.14, 1.36) | 1.49 (1.1, 2.03) | 1.42 (1.24, 1.63) | < 0.001 |
| Sensitivity-3 | n | 12,722 | 3023 | 124 | – | – |
| CAP case | 2698 | 968 | 53 | – | – |
| Multivariate adjusted | Ref | 1.27 (1.17, 1.39) | 1.54 (1.14, 2.08) | 1.47 (1.29, 1.68) | < 0.001 |
| Sensitivity-4 | n | 13,417 | 3296 | 150 | – | – |
| CAP case | 2835 | 1044 | 63 | – | – |
| Multivariate adjusted | Ref | 1.26 (1.16, 1.37) | 1.52 (1.16, 2.01) | 1.44 (1.27, 1.64) | < 0.001 |
| Sensitivity-5a | n | 1135 | 1247 | 1064 | – | – |
| CAP case | 315 | 404 | 388 | – | – |
| Multivariate adjusted | Ref | 1.12 (0.96, 1.3) | 1.24 (1.05, 1.46) | 1.61 (1.08, 2.39) | 0.02 |
- Adjusting age (year), sex, and BMI (kg/m2), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low density lipoprotein cholesterol (mmol/L), high density lipoprotein cholesterol (mmol/L), eGFR (mL/min/1.73 m2), fasting blood glucose (mmol/L) at baseline
- Sensitivity-1: cumulative average of HbA1c during 2014–2019 was used as the exposure
- Sensitivity-2: excluding those with high concentration of high sensitivity C-reactive protein (≥ 3 mg/L) at baseline (n = 1149)
- Sensitivity-3: excluding those with high level of white blood cell (≥ 9.0 × 109/L) at baseline (n = 994)
- Sensitivity-4: excluding those with high fasting blood glucose (≥ 5.6 mmol/L) at baseline (n = 2001)
- Sensitivity-5: excluding those with normal level of HbA1c at baseline (n = 13,417)
- aTertiled by baseline HbA1c
