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Table 3 Adjusted hazardous ratios and 95% confidence intervals for risks of incident diabetes across different HbA1c groups during 5-year follow up: sensitivity analyses

From: Prospective study of hemoglobin A1c and incident carotid artery plaque in Chinese adults without diabetes

 ModelHbA1c groupsEach percent of HbA1cp trend
≤ 5.6%5.7–6.4%≥ 6.5%
Sensitivity-1n12,5624083218
CAP case1947195144
Multivariate adjustedRef3.01 (2.81, 3.23)1.42 (1.04, 1.95)2.94 (2.67, 3.22)< 0.001
Sensitivity-2n12,6362959119
CAP case264992150
Multivariate adjustedRef1.25 (1.14, 1.36)1.49 (1.1, 2.03)1.42 (1.24, 1.63)< 0.001
Sensitivity-3n12,7223023124
CAP case269896853
Multivariate adjustedRef1.27 (1.17, 1.39)1.54 (1.14, 2.08)1.47 (1.29, 1.68)< 0.001
Sensitivity-4n13,4173296150
CAP case2835104463
Multivariate adjustedRef1.26 (1.16, 1.37)1.52 (1.16, 2.01)1.44 (1.27, 1.64)< 0.001
Sensitivity-5an113512471064
CAP case315404388
Multivariate adjustedRef1.12 (0.96, 1.3)1.24 (1.05, 1.46)1.61 (1.08, 2.39)0.02
  1. Adjusting age (year), sex, and BMI (kg/m2), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low density lipoprotein cholesterol (mmol/L), high density lipoprotein cholesterol (mmol/L), eGFR (mL/min/1.73 m2), fasting blood glucose (mmol/L) at baseline
  2. Sensitivity-1: cumulative average of HbA1c during 2014–2019 was used as the exposure
  3. Sensitivity-2: excluding those with high concentration of high sensitivity C-reactive protein (≥ 3 mg/L) at baseline (n = 1149)
  4. Sensitivity-3: excluding those with high level of white blood cell (≥ 9.0 × 109/L) at baseline (n = 994)
  5. Sensitivity-4: excluding those with high fasting blood glucose (≥ 5.6 mmol/L) at baseline (n = 2001)
  6. Sensitivity-5: excluding those with normal level of HbA1c at baseline (n = 13,417)
  7. aTertiled by baseline HbA1c