Table 3 Hazard ratios (HRs) and 95% confidence intervals for the incidence of cardiovascular disease and all-cause mortality during follow up according to the presence, type, and duration of diabetes mellitus

Myocardial infarction

 Events (n)

83,712

14,986

17,680

257

14

 Follow-up duration (person-years)

84,157,841.27

5,516,027.03

3,677,744.08

41,701.72

2,604.79

 Incidence rate (per 100,000 person-years)

99.470

271.681

480.729

616.282

537.471

 Model 1

1 (Ref.)

1.635 (1.607–1.664)

2.135 (2.100–2.171)

3.295 (2.915–3.724)

3.904 (2.314–6.586)

–

1 (Ref.)

1.387 (1.357–1.418)

2.072 (1.832–2.344)

2.343 (1.387–3.956)

 Model 2

1 (Ref.)

1.394 (1.369–1.419)

1.837 (1.807–1.868)

2.825 (2.499–3.193)

3.303 (1.958–5.573)

–

1 (Ref.)

1.374 (1.344–1.405)

2.044 (1.807–2.313)

2.295 (1.359–3.875)

 Model 3

1 (Ref.)

1.361 (1.336–1.386)

1.792 (1.761–1.823)

2.729 (2.414–3.085)

3.136 (1.857–5.295)

–

1 (Ref.)

1.385 (1.355–1.416)

2.025 (1.790–2.291)

2.247 (1.331–3.796)

 Model 4

1 (Ref.)

1.250 (1.226–1.276)

1.628 (1.596–1.661)

2.418 (2.137–2.735)

2.830 (1.677–4.774)

–

1 (Ref.)

1.351 (1.321–1.381)

1.955 (1.728–2.212)

2.200 (1.303–3.715)

Hospitalization for HF

 Events (n)

89,173

15,926

20,522

358

18

 Follow-up duration (person-years)

84,188,450.19

5,521,605.87

3,681,471.67

41,639.93

2,598.64

 Incidence rate (per 100,000 person-years)

105.921

288.431

557.440

859.752

692.670

 Model 1

1 (Ref.)

1.515 (1.490–1.541)

1.999 (1.969–2.030)

3.922 (3.536–4.351)

4.682 (2.958–7.411)

–

1 (Ref.)

1.373 (1.345–1.402)

2.624 (2.363–2.913)

3.063 (1.934-4.851)

 Model 2

1 (Ref.)

1.381 (1.357–1.405)

1.841 (1.813–1.870)

3.578 (3.225–3.969)

4.196 (2.650–6.643)

–

1 (Ref.)

1.371 (1.343–1.400)

2.596 (2.338–2.883)

3.000 (1.894–4.750)

 Model 3

1 (Ref.)

1.364 (1.340–1.388)

1.802 (1.774–1.831)

3.379 (3.045–3.749)

3.927 (2.474–6.234)

–

1 (Ref.)

1.371 (1.343–1.400)

2.495 (2.247–2.771)

2.843 (1.791–4.514)

 Model 4

1 (Ref.)

1.236 (1.212–1.260)

1.626 (1.596–1.656)

3.036 (2.734–3.371)

3.535 (2.232–5.597)

–

1 (Ref.)

1.346 (1.318–1.375)

2.452 (2.208–2.723)

2.787 (1.756–4.426)

Atrial fibrillation

 Events (n)

105,562

15,019

14,724

213

14

 Follow-up duration (person-years)

84,127,796.33

5,518,697.12

3,686,232.26

41,821.14

2,604.57

 Incidence rate (per 100,000 person-years)

125.478

272.148

399.432

509.312

537.517

 Model 1

1 (Ref.)

1.242 (1.221–1.264)

1.296 (1.273–1.318)

2.029 (1.774–2.321)

3.015 (1.787–5.086)

–

1 (Ref.)

1.072 (1.048–1.097)

1.654 (1.445–1.894)

2.381 (1.412–4.014)

 Model 2

1 (Ref.)

1.117 (1.098–1.136)

1.180 (1.159–1.201)

1.846 (1.614–2.112)

2.705 (1.603–4.563)

–

1 (Ref.)

1.081 (1.057–1.107)

1.669 (1.458–1.911)

2.378 (1.411–4.008)

 Model 3

1 (Ref.)

1.124 (1.105–1.144)

1.171 (1.150–1.192)

1.793 (1.567–2.051)

2.650 (1.570–4.475)

–

1 (Ref.)

1.070 (1.045–1.095)

1.610 (1.407–1.844)

2.297 (1.360–3.880)

 Model 4

1 (Ref.)

1.060 (1.039–1.081)

1.114 (1.091–1.137)

1.714 (1.497–1.962)

2.508 (1.486–4.232)

–

1 (Ref.)

1.074 (1.050–1.099)

1.637 (1.430–1.875)

2.332 (1.384–3.930)

All-cause mortality

 Events (n)

249,622

45,145

48,873

841

35

 Follow-up duration (person-years)

84,326,798.16

5,547,858.83

3,713,739.98

42,168.61

2,620.17

 Incidence rate (per 100,000 person-years)

296.020

813.740

1,316.000

1,994.370

1,335.790

 Model 1

1 (Ref.)

1.483 (1.468–1.498)

1.659 (1.643–1.675)

3.150 (2.944–3.370)

2.917 (2.094–4.062)

–

1 (Ref.)

1.132 (1.118–1.147)

2.124 (1.984–2.274)

1.979 (1.422–2.755)

 Model 2

1 (Ref.)

1.588 (1.572–1.604)

1.787 (1.770–1.805)

3.355 (3.136–3.589)

3.072 (2.206–4.278)

–

1 (Ref.)

1.139 (1.124–1.154)

2.101 (1.962–2.249)

1.927 (1.384–2.684)

 Model 3

1 (Ref.)

1.533 (1.517–1.549)

1.745 (1.727–1.763)

3.135 (2.930–3.355)

2.891 (2.075–4.026)

–

1 (Ref.)

1.154 (1.139–1.169)

2.044 (1.909–2.188)

1.884 (1.353–2.625)

 Model 4

1 (Ref.)

1.434 (1.417–1.451)

1.598 (1.579–1.617)

2.893 (2.703–3.097)

2.638 (1.894–3.674)

–

1 (Ref.)

1.124 (1.109–1.138)

2.009 (1.876–2.151)

1.836 (1.319–2.557)