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Table 2 Changes in lipoprotein subclasses after treatment with liraglutide vs. placebo

From: Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial

Lipoprotein subclasses Placebo Liraglutide P1 P2
Visit 1 Visit 6 Delta changes Visit 1 Visit 6 Delta changes
LDL
 Concentration of particles of different size
  S-LDL-P (× 10−4) 1.4 ± 0.31 1.47 ± 0.33 0.07 ± 0.04 1.37 ± 0.31 1.28 ± 0.29 − 0.09 ± 0.05 0.01 0.13
  M-LDL-P (× 10−4) 1.2 ± 0.27 1.27 ± 0.28 0.07 ± 0.04 1.18 ± 0.26 1.11 ± 0.25 − 0.08 ± 0.05 0.02 0.15
 Concentration of lipids in particles of different size
  S-LDL-L 0.39 ± 0.09 0.41 ± 0.09 0.02 ± 0.012 0.39 ± 0.09 0.36 ± 0.081 − 0.03 ± 0.01 0.01 0.01
  S-LDL-PL (× 10−2) 12.5 ± 2.78 12.9 ± 2.87 0.42 ± 0.25 12.2 ± 2.72 11.6 ± 2.6 − 0.55 ± 0.25 0.01 0.01
  S-LDL-FC (× 10−2) 7.23 ± 1.61 7.48 ± 1.67 0.25 ± 0.17 7.14 ± 1.6 6.75 ± 1.51 − 0.4 ± 0.2 0.02 0.01
  M-LDL-L 0.61 ± 0.14 0.65 ± 0.14 0.03 ± 0.02 0.6 ± 0.14 0.57 ± 0.13 − 0.04 ± 0.02 0.02 0.01
  M-LDL-PL 17.3 ± 3.86 18 ± 4.02 0.73 ± 0.4 16.9 ± 3.78 16.2 ± 3.62 − 0.75 ± 0.43 0.01 0.01
 Concentration of lipids relative to total lipids in particles of different size
  S-LDL-PL_% 31.9 ± 7.12 31.4 ± 7.03 − 0.44 ± 0.44 31.9 ± 7.13 32.6 ± 7.28 0.65 ± 0.5 0.08 0.01
  S-LDL-CE_% 43.2 ± 9.68 44 ± 9.85 0.81 ± 0.76 43.3 ± 9.68 42.4 ± 9.49 − 0.89 ± 0.8 0.12 0.02
  S-LDL-FC_% 18.5 ± 4.12 18.2 ± 4.07 − 0.26 ± 0.14 18.6 ± 4.17 18.8 ± 4.21 0.19 ± 0.15 0.02 0.002
  M-LDL-PL_% 28.4 ± 6.34 28.1 ± 6.28 − 0.29 ± 0.36 28.4 ± 6.35 29 ± 6.48 0.57 ± 0.43 0.11 0.02
  M-LDL-CE_% 45 ± 10.1 46 ± 10.3 1 ± 0.7 45 ± 10.1 44.2 ± 9.89 − 0.81 ± 0.82 0.08 0.02
  M-LDL-FC_% 19.8 ± 4.43 19.5 ± 4.36 − 0.34 ± 0.17 20 ± 4.48 20.3 ± 4.55 0.3 ± 0.24 0.02 0.002
HDL
 Concentration of lipids relative to total lipid concentration in the particles of different size
  L-HDL-C_% 44.9 ± 10 43.2 ± 9.63 − 1.52 ± 2.67 45.8 ± 10.2 45 ± 10.1 6.15 ± 3.55 0.03 0.12
  L-HDL-CE_% 36.4 ± 8.11 35.2 ± 7.85 − 1.03 ± 2.31 36.6 ± 8.19 36.7 ± 8.21 5.59 ± 3.06 0.02 0.09
  XL-HDL-PL_% 43.6 ± 9.82 43.5 ± 9.75 − 2.28 ± 1.88 44.5 ± 9.94 46.3 ± 10.4 1.76 ± 0.97 0.05 0.1
  XL-HDL-CE_% 41.5 ± 9.2 42.4 ± 9.44 0.93 ± 0.91 40.6 ± 9.08 39.1 ± 8.75 − 1.43 ± 0.74 0.03 0.08
VLDL
 Concentration of particles of different size
  XS-VLDL-P (× 10−4) 0.35 ± 0.08 0.36 ± 0.08 0.016 ± 0.009 0.34 ± 0.08 0.33 ± 0.07 − 0.01 ± 0.01 0.04 0.31
 Concentration of lipids in particles of different size 
  XS-VLDL-L 0.44 ± 0.1 0.46 ± 0.1 0.02 ± 0.01 0.43 ± 0.1 0.42 ± 0.09 − 0.01 ± 0.01 0.04 0.04
  XS-VLDL-PL (× 102) 12.9 ± 2.88 13.5 ± 3.01 0.58 ± 0.39 12.6 ± 2.81 12.1 ± 2.71 − 0.42 ± 0.43 0.06 0.03
  S-VLDL-C 17.3 ± 3.88 19.3 ± 4.32 1.98 ± 0.69 17 ± 3.8 17.2 ± 3.85 0.19 ± 0.78 0.04 0.08
  S-VLDL-CE 0.11 ± 0.02 0.12 ± 0.03 0.01 ± 0.005 0.11 ± 0.02 0.11 ± 0.02 0.001 ± 0.01 0.04 0.07
IDL
 Concentrations of lipids relative to total lipid concentration in particles of different size
  IDL-P (× 10−4) 0.92 ± 0.2 0.93 ± 0.21 − 0.03 ± 0.06 0.9 ± 0.2 0.85 ± 0.19 − 0.05 ± 0.03 0.81 0.85
  IDL-PL_% 27.8 ± 6.21 27.7 ± 6.18 − 0.12 ± 0.09 27.9 ± 6.23 27.9 ± 6.25 0.08 ± 0.11 0.11 0.15
  IDL-C_% 61.6 ± 13.8 61.9 ± 13.8 3.37 ± 2.96 61.4 ± 13.7 61.1 ± 13.7 − 0.3 ± 0.43 0.25 0.01
  IDL-CE_% 43.7 ± 9.78 44.4 ± 9.93 0.67 ± 0.22 43.7 ± 9.78 43.6 ± 9.75 − 0.12 ± 0.36 0.04 0.04
  1. Values are given in mmol/L. P1—Delta statistics unadjusted. P2—Delta changes adjusted for changes in weight. Values are reported as mean ± SE. On treatment analysis was performed for all variables. The level of significance was set to p-value < 0.05 after Bonferroni correction. Baseline samples collected at visit 1, post treatment samples were collected at visit 6 (5 weeks of treatment total)
  2. S-LDL-P concentration of small LDL particles, M-LDL-P concentration of medium LDL particles, S-LDL-L total lipids in small LDL, S-LDL-PL phospholipids in small LDL, S-LDL-FC free cholesterol in small LDL, M-LDL-L total lipids in medium LDL, M-LDL-PL phospholipids in medium LDL, S-LDL-PL_% phospholipids to total lipids ratio in small LDL, S-LDL-CE_% cholesterol esters to total lipids ratio in small LDL, S-LDL-FC_% free cholesterol to total lipids ratio in small LDL, M-LDL-PL_% phospholipids to total lipids ratio in medium LDL, M-LDL-CE_% cholesterol esters to total lipids ratio in medium LDL, M-LDL-FC_% free cholesterol to total lipids ratio in medium LDL, L-HDL-C_% total cholesterol to total lipids ratio in large HDL, L-HDL-CE_% cholesterol esters to total lipids ratio in large HDL, XL-HDL-PL_% phospholipids to total lipids ratio in very large HDL, XL-HDL-CE_% cholesterol esters to total lipids ratio in very large HDL, XS-VLDL-PL phospholipids to total lipids ratio in very small VLDL, S-VLDL-C total cholesterol in small VLDL, S-VLDL-CE cholesterol esters in small VLDL, IDL-P concentration of IDL particles, IDL-PL phospholipids in IDL, IDL-C total cholesterol in IDL, IDL-CE cholesterol esters in IDL
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