Fig. 3

Diabetic cardiomyopathy phenotype in Europeans and South Asians. a Impaired LV diastolic function, as indicated by a lower ratio of the transmitral early and late peak filling rate (E/A) was identified as a common characteristic of diabetic cardiomyopathy in Europeans and South Asians. The E/A ratio was measured using 4D velocity-encoded MR after retrospective mitral valve tracking and through-plane motion correction (left image). An example of the transmitral flow rate curve in a T2D patient (South Asian 62-year-old woman with E/A: 0.95) and control (South Asian 57-year-old women with E/A: 1.25) is provided (right images). b In South Asian but not in European T2D patients the LV mass, measured on short-axis cine (upper image), was higher than in the control group and the extracellular volume fraction, measured in the mid-ventricular septum using T1 mapping (lower image), was decreased. In the presented South Asian T2D patient, LV mass was 97 g and extracellular volume fraction was 27%. c Among Europeans but not among South Asians the myocardial triglyceride content was different for T2D patients compared with controls. An example of cardiac proton-magnetic resonance spectroscopy (¹H-MRS) in a 45-year-old woman with T2D (left image) and in a 48-year-old non-diabetic woman (right image) of European descent is provided (myocardial triglyceride content (MTGC): 1.24% and 0.60%, respectively)