Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes

Table 2 The associations of present T2D and T2D-GRS with multi-vessel disease

	T2D cases/total subjects	Model 1^a		Model 2^b		Model 3^c
	T2D cases/total subjects	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Present T2D	288/1414	1.79 (1.33–2.44)	< 0.001	1.69 (1.25–2.32)	< 0.001	–	–
Continuous variable of GRS
Per SD (3.81 points)		1.23 (1.10–1.37)	< 0.001	1.21 (1.08–1.36)	< 0.001	1.16 (1.03–1.31)	0.012
Per risk allele		1.06 (1.02–1.09)	< 0.001	1.05 (1.02–1.08)	< 0.001	1.04 (1.01–1.07)	0.012
Categorical variable of GRS
Low risk	43/472	1.00	0.011	1.00	0.021	1.00	0.126
Medium risk	78/471	1.12 (0.86–1.47)		1.11 (0.84–1.46)		1.08 (0.82–1.42)
High risk	167/471	1.43 (1.08–1.89)		1.39 (1.05–1.84)		1.25 (0.94–1.67)

^aAdjust for age, sex and BMI
^bAdjust for age, sex, BMI, smoking, hypertension, and hypercholesterolemia
^cAdjust for age, sex, BMI, smoking, hypertension, hypercholesterolemia, and T2D

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