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Table 2 The associations of present T2D and T2D-GRS with multi-vessel disease

From: Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes

  T2D cases/total subjects Model 1a Model 2b Model 3c
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Present T2D 288/1414 1.79 (1.33–2.44) < 0.001 1.69 (1.25–2.32) < 0.001
Continuous variable of GRS
 Per SD (3.81 points)   1.23 (1.10–1.37) < 0.001 1.21 (1.08–1.36) < 0.001 1.16 (1.03–1.31) 0.012
 Per risk allele   1.06 (1.02–1.09) < 0.001 1.05 (1.02–1.08) < 0.001 1.04 (1.01–1.07) 0.012
Categorical variable of GRS
 Low risk 43/472 1.00 0.011 1.00 0.021 1.00 0.126
 Medium risk 78/471 1.12 (0.86–1.47)   1.11 (0.84–1.46)   1.08 (0.82–1.42)  
 High risk 167/471 1.43 (1.08–1.89)   1.39 (1.05–1.84)   1.25 (0.94–1.67)  
  1. aAdjust for age, sex and BMI
  2. bAdjust for age, sex, BMI, smoking, hypertension, and hypercholesterolemia
  3. cAdjust for age, sex, BMI, smoking, hypertension, hypercholesterolemia, and T2D