Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study

Table 2 Pearson correlation coefficients between log-transformed hsCRP and HOMA-IR at baseline and follow-up in the total cohort and subgroups, adjusted for covariates

Group	Variable	Baseline hsCRP	Baseline HOMA-IR	Follow-up hsCRP
Total^a	Baseline HOMA-IR	0.102
	Follow-up hsCRP	0.473	0.053
	Follow-up HOMA-IR	0.147	0.418	0.187
White/black^b	Baseline HOMA-IR	0.108/0.090
	Follow-up hsCRP	0.494/0.416	0.082/− 0.014
	Follow-up HOMA-IR	0.154/0.152	0.437/0.369	0.248/0.043*
Male/female^c	Baseline HOMA-IR	0.036/0.139
	Follow-up hsCRP	0.444/0.495	0.029/0.068
	Follow-up HOMA-IR	0.060/0.190	0.460/0.396	0.161/0.201
Normo/hyper^d	Baseline HOMA-IR	0.146/0.043
	Follow-up hsCRP	0.483/0.455	0.034/0.064
	Follow-up HOMA-IR	0.129/0.175	0.340/0.437	0.121/0.268

Covariates included in the models were race, sex, age, BMI, smoking and alcohol use for the total sample and Normo/Hyper groups, with additional adjustment for follow-up years for baseline-follow-up correlations
hsCRP, high-sensitivity C-reactive protein; HOMA-IR, homeostasis model assessment for insulin resistance; Normo, normoglycemia in the outcome survey; Hyper, hyperglycemia in the outcome survey
^aCorrelation coefficients greater than 0.087 are significant (p < 0.05)
^bCorrelation coefficients greater than 0.103 for whites and 0.161 for blacks are significant (p < 0.05)
^cCorrelation coefficients greater than 0.148 for males, and 0.108 for females are significant (p < 0.05)
^dCorrelation coefficients greater than 0.118 for normoglycemia, and 0.129 for hyperglycemia are significant (p < 0.05)
* p < 0.05 for race difference

ISSN: 1475-2840