A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients

Table 3 Association between rs9267551 and MI in the two study samples

Study samples	DDAH2 rs9267551 genotype			Additive model (unadjusted)		Additive model
CZ (n = 1060)	GG	GC	CC	OR (95% CI)	p	OR (95% CI)	p
MI-neg (n = 883)	796 (90.1%)	83 (9.4%)	4 (0.5%)	0.380 (0.175–0.823)	0.014	0.342 (0.146–0.799)	0.013^a
						0.307 (0.106–0.885)	0.029^b
MI-pos (n = 177)	170 (96.0%)	7 (4.0%)	0 (0%)			0.364 (0.121–1.102)	0.074^c

GHS (n = 779)	GG	GC	CC	OR (95% CI)	p	OR (95% CI)	p
M-neg (n = 595)	522 (87.7%)	70 (11.8%)	3 (0.5%)	0.497 (0.267–0.923)	0.027	0.503 (0.269–0.941)	0.031^a
						0.512 (0.270–0.970)	0.040^b
MI-pos (n = 184)	172 (93.5%)	12 (6.5%)	0 (0%)			0.478 (0.245–0.935)	0.031^c

Pooled (n = 1839)	GG	GC	CC	OR (95% CI)	p	OR (95% CI)	p
MI-neg (n = 1478)	1318 (89.2%)	153 (10.3%)	7 (0.5%)	0.458 (0.283–0.739)	0.001	0.445 (0.270–0.733)	0.001^d
						0.458 (0.266–0.787)	0.005^e
MI-pos (n = 361)	342 (94.7%)	19 (5.3%)	0 (0%)			0.457 (0.259–0.808)	0.007^f

CZ Catanzaro Study, GHS Gargano Heart Study
^aAdjusted for sex, age, BMI, smoking habit
^bAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol and triglycerides levels
^cAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration and therapies
^dAdjusted for sex, age, BMI, smoking habit and study center
^eAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels and study center
^fAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration, therapies and study center

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