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Table 2 Impact of lipid profile on poor collateralization in patients with and without diabetes

From: Lipoprotein (a) interactions with cholesterol-containing lipids on angiographic coronary collateralization in type 2 diabetic patients with chronic total occlusion

  Tertiles of lipid profile Overall (n = 1284) Diabetes (n = 706) Non-diabetes (n = 578)
Range n Poor/good Adjusted OR (95% CI)a P value Poor/good Adjusted OR (95% CI)a P value Poor/good Adjusted OR (95% CI)a P value
Lp(a) Per tertile, mg/dL    1.394 (1.192–1.629) < 0.001*   1.366 (1.108–1.684) 0.003*   1.432 (1.119–1.831) 0.004*
T1 < 12.66 426 128/298 1 80/147 1 48/151 1
12.66 ≤ T2 < 30.23 449 176/273 1.170 (0.861–1.591) 0.316 117/134 1.282 (0.854–1.926) 0.231 59/139 1.040 (0.640–1.688) 0.875
T3 ≥ 30.23 409 201/208 1.929 (1.413–2.633) < 0.001 126/102 1.863 (1.227–2.830) 0.004 75/106 2.010 (1.236–3.269) 0.005
Total cholesterol Per tertile, mmol/L    1.791 (1.475–2.174) < 0.001*   1.814 (1.393–2.361) < 0.001*   1.820 (1.358–2.440) < 0.001*
T1 < 4.26 420 123/297 1 66/129 1 57/168 1
4.26 ≤ T2 < 5.35 441 170/271 1.612 (1.168–2.224) 0.004 109/129 1.993 (1.251–3.173) 0.004 61/142 1.357 (0.854–2.158) 0.196
T3 ≥ 5.35 423 212/211 3.221 (2.186–4.747) < 0.001 148/125 3.337 (1.962–5.674) < 0.001 64/86 3.663 (2.010–6.675) < 0.001
LDL-C Per tertile, mmol/L    1.748 (1.441–2.122) < 0.001*   1.830 (1.407–2.381) < 0.001*   1.699 (1.270–2.274) < 0.001*
T1 < 2.58 401 115/286 1 61/138 1 54/148 1
2.58 ≤ T2 < 3.36 431 171/260 1.620 (1.164–2.255) 0.004 116/115 2.426 (1.518–3.879) < 0.001 55/145 1.052 (0.648–1.709) 0.837
T3 ≥ 3.36 452 219/233 3.048 (2.070–4.488) < 0.001 146/130 3.509 (2.064–5.964) < 0.001 73/103 3.092 (1.724–5.548) < 0.001
Non-HDL-C Per tertile, mmol/L    1.828 (1.498–2.230) < 0.001*   1.810 (1.386–2.364) < 0.001*   1.912 (1.407–2.597) < 0.001*
T1 < 3.30 436 131/305 1 71/131 1 60/174 1
3.30 ≤ T2 < 4.38 441 167/274 1.540 (1.122–2.113) 0.008 104/133 1.683 (1.073–2.639) 0.023 63/141 1.407 (0.891–2.222) 0.143
T3 ≥ 4.38 407 207/200 3.422 (2.293–5.108) < 0.001 148/119 3.263 (1.911–5.571) < 0.001 59/81 4.260 (2.245–8.086) < 0.001
HDL-C Per tertile, mmol/L    0.907 (0.775–1.060) 0.220*   0.846 (0.686–1.045) 0.121*   0.994 (0.780–1.267) 0.960*
T1 < 0.86 388 172/216 1 117/112 1 55/104 1
0.86 ≤ T2 < 1.04 437 161/276 0.809 (0.596–1.098) 0.174 101/133 0.808 (0.540–1.210) 0.302 60/143 0.834 (0.514–1.354) 0.463
T3 ≥ 1.04 459 172/287 0.820 (0.600–1.121) 0.214 105/138 0.717 (0.471–1.093) 0.122 67/149 0.975 (0.602–1.579) 0.918
Triglyceride Per tertile, mmol/L    1.075 (0.914–1.266) 0.383*   1.092 (0.880–1.352) 0.428*   1.055 (0.816–1.365) 0.683*
T1 < 1.28 436 158/278 1 96/122 1 62/156 1
1.28 ≤ T2 < 1.84 448 175/273 1.109 (0.822–1.497) 0.498 99/135 0.947 (0.625–1.434) 0.796 76/138 1.311 (0.840–2.046) 0.232
T3 ≥ 1.84 400 172/228 1.155 (0.833–1.600) 0.387 128/126 1.183 (0.771–1.817) 0.442 44/102 1.072 (0.633–1.814) 0.796
  1. CI confidence interval, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, Lp(a) lipoprotein a, OR odds ratio
  2. * P for trend for tertiles of lipid profile
  3. aMultiple adjustment for gender, age, body mass index, hypertension, diabetes, dyslipidemia, smoking, prior myocardial infarction, multi-vessel disease, glomerular filtration rate, log-transferred high-sensitivity C reactive protein and left ventricular ejection fraction