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Table 2 Changes of each blood and urine test

From: Canagliflozin for Japanese patients with chronic heart failure and type II diabetes

 

Pre

1 month

3 months

6 months

12 months

Body weight (kg)

66.7 ± 3.6

64.7 ± 3.5*

63.8 ± 3.5*#

Body mass index

25.6 ± 1.1

24.7 ± 1.0*

24.3 ± 1.0*

Metabolic syndrome

19 (54%)

10 (29%)

8 (23%)*

Hemoglobin (g/dL)

12.5 ± 0.4

12.6 ± 0.4

12.7 ± 0.4

12.8 ± 0.4

13.3 ± 0.4*$+

Hematocrit (%)

38.0 ± 1.1

38.4 ± 1.2

38.3 ± 1.2

38.6 ± 1.2

40.7 ± 1.2*$+#

HbA1c (%)

6.61 ± 0.20

6.51 ± 0.21*

6.52 ± 0.19

6.31 ± 0.19*$+

6.29 ± 0.19*$+

Insulin (μlU/mL)

13.8 ± 3.2

18.3 ± 5.4

12.9 ± 2.5

13.8 ± 3.2

CPR (ng/mL)

4.21 ± 0.35

4.36 ± 0.48

4.00 ± 0.39

3.47 ± 0.29+

Blood urea nitrogen (mg/dL)

22.0 ± 1.5

22.2 ± 1.5

22.5 ± 1.3

22.0 ± 1.4

20.8 ± 1.2

Total cholesterol (mg/dL)

147.4 ± 6.1

148.0 ± 6.2

147.4 ± 5.9

145.3 ± 5.8

143.1 ± 5.3

LDL (mg/dL)

82.4 ± 4.8

82.5 ± 4.1

82.4 ± 4.0

79.5 ± 4.1

70.4 ± 3.9*$+#

HDL (mg/dL)

52.6 ± 2.5

54.2 ± 2.5*

54.4 ± 2.4*

55.5 ± 2.4*

59.2 ± 3.0*$+#

nonHDL (mg/dL)

96.9 ± 4.6

95.8 ± 4.6

95.0 ± 4.1

91.9 ± 4.1

86.1 ± 3.5*$+

Triglyceride (mg/dL)

159.2 ± 19.0

122.5 ± 11.5*

111.7 ± 10.0*

108.2 ± 11.4*

107.7 ± 10.2*$

RLP-cho (mg/dL)

5.89 ± 0.94

4.56 ± 0.58*

4.48 ± 0.71*

3.69 ± 0.62*+#

EPA/AA

0.52 ± 0.07

0.53 ± 0.07

0.55 ± 0.06

0.57 ± 0.06

hs-CRP (hs-CRP)

0.39 ± 0.07

0.27 ± 0.06

0.20 ± 0.05*

0.20 ± 0.04*

0.21 ± 0.04*

Renin (pg/mL)

10.3 ± 3.9

29.6 ± 8.5*

44.4 ± 10.7*

50.7 ± 16.6*

Angiotensin-II (pg/mL)

30.0 ± 5.8

29.1 ± 5.2

20.2 ± 3.3*+

23.1 ± 5.7

Aldosterone (pg/mL)

219.6 ± 30.3

177.9 ± 24.8*

171.3 ± 21.9*

169.2 ± 24.2*

Urine sugar

0.46 ± 0.19

3.63 ± 0.12

3.57 ± 0.12

3.46 ± 0.12

3.46 ± 0.12

Urine ketone

0

0.03 ± 0.03

0

0

0.06 ± 0.04

  1. HbA1c hemoglobin A1c, CPR C-peptide immunoreactivity, LDL low density lipoprotein, HDL high density lipoprotein, RLP-cho remnant like particles-cholesterol, EPA eicosapentaenoic acid, AA arachidonic acid, hs-CRP high-sensitivity C-reactive protein
  2. p < 0.05, pre vs. each level, $ p < 0.05, 1 month vs. each level, + p < 0.05, 3 months vs. each level, # p < 0.05, 6 months vs. each level